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Topiramate
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Topiramate

Topiramate is a broad spectrum, antiepileptic drug used for various types of seizures, Lennox-Gastaut syndrome (a type of childhood onset epilepsy), and migraine prophylaxis. Topiramate blocks voltage-dependent sodium channels, potentiates gamma-aminobutyric acid (GABA) activity at some of the GABA receptors, and inhibits potentiation of the glutamate receptor and carbonic anhydrase enzyme, which all contribute to its antiepileptic and antimigraine efficacy.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Endocytoscopy allows visualization of the superficial mucosal layer. Chinese translation and validation of the questionnaire on the process of recovery in schizophrenia and other psychotic disorders. We previously demonstrated that TSP-1 binds to FGF-2, sequestering the growth factor and inhibiting its angiogenic activity. We found that 8 of the apparatuses checked were inaccurate by as much as 350 mmHg, 8 had defective valves and 1 was considered to be too dangerous for further clinical use.

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Noninvasive biomarkers, especially sputum inflammatory cell counts, aid phenotyping and are useful outcome measures for novel, targeted therapies. Determining the most robust dimensional structure of categories from the international classification of functioning, disability and health across subgroups of persons with spinal cord injury to build the basis for future clinical measures. A deficit in global motion and form perception was only evident in strabismic amblyopia. Chiral capillary liquid chromatography based on penicillin G acylase immobilized on monolithic epoxy silica column.

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An analysis and discussion of all the available data was conducted to develop a comprehensive primary health care service utilization and resources inventory at the polyclinics. Our characterization includes the effective RI change caused by the thickness, functional volume ratio, and functional strength of the hydrogel layer. Malignant hyperthermia presenting during laparoscopic adrenalectomy. Demanding kin relations and depressive symptoms among low-income African American women: mediating effects of self-esteem and optimism. Our data suggest that preoperative CRT may improve the survival of surgically treated patients with external auditory canal SCC and that definitive CRT may be equivalent to surgical resection.

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Aqueous ammonia soaking of switchgrass followed by simultaneous saccharification and fermentation. However the molecular mechanisms underlying this phenomenon still need to be elucidated. We then review two published studies that used MI in different ways to foster EX/RP participation. The investigation was made in rabbits maintained either under a 12-h light/dark (LD) cycle or under conditions of continuous light (LL). Hepatitis B revaccination of neonates with inadequate response after primovaccination.

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A correlation between an increased RDW and prostate volume was suggested by the new data from this study. Recently, some investigators have shown that telmisartan, an angiotensin II (Ang II)-receptor blocker (ARB), is a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). The possible impact of the rocket fuel 1,1-dimethyl hydrazine (heptyl) (1) and its transformation products on human health has been studied using (Quantitative) Structure Activity/Toxicity ((Q)SAR/(Q)STR) modelling, including both ADME models and models for acute toxicity, organ specific adverse haematological effects, the cardiovascular and gastrointestinal systems, the kidneys, the liver and the lungs, as well as a model predicting the biological activity of the compounds. Adolescents reported endorsing the concept of the app and the implementation of a peer mentoring system in particular.

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A recent network meta-analysis (NMA) evaluated the relative efficacy of CNIs ciclosporin, prolonged-release (PR) tacrolimus, and immediate-release (IR) tacrolimus in adult liver transplant recipients based on randomized and large observational trials published since 2000. The smears were graded for cell yield and dispersion on a three-point scale. MoS2 nanodot decorated In2S3 nanoplates: a novel heterojunction with enhanced photoelectrochemical performance.

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Though most of the psychiatric centers in the armed forces have this facility, not much work has been done in our setup to assess its efficacy in the management of anxiety. This correlated with a significant change in two-dimensional migratory speed.

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In this study, we construct systematic models for the insulin signaling network mediated by IRS1 and IRS2, through the integration of current knowledge in the literature into mathematical models of insulin signaling pathways. The 100 ml of canal water samples of 36 canals in Bangkok Metropolitan Area were examined in three periods starting from July-September 1988, November 1988-January 1989 and February-April 1989. Neonatal pigs were evaluated as a model for protein metabolism of infants.

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Our results show that SCRS can serve as a label-free and non-invasive proxy for quantitatively tracking and screening cellular TAG content in real-time at single-cell level. Multiphenotypic acute leukemias: clinicopathologic correlations and response to therapy. Asparagine is an important nitrogen storage and transport molecule, but its accumulation as a free amino acid in crops has implications for food safety because free asparagine is a precursor for acrylamide formation during cooking and processing. A new therapy for the progesterone receptor positive mammary carcinoma may be the treatment with progesterone antagonists.

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A mathematics-based new penalty area in football: tackling diving. Is arterial stiffness predicted by continuous metabolic syndrome score in obese children? Based on these data high lipocalin 2 expression level seems to have strong positive predictive value on thrombotic events in patients with polycythemia vera and essential thrombocythemia.

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Risk perceptions of MSF healthcare workers on the recent Ebola epidemic in West Africa. The cystine/glutamate antiporter system xc(-) imports cystine while exporting glutamate, thereby promoting glutathione synthesis while increasing extracellular cerebral glutamate. Docetaxel and Cisplatin Combination Chemotherapy in Patients with Squamous Cell Carcinomas of the Head and Neck.

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In schizophrenia, patients display dysfunctions during the execution of simple visual tasks such as antisaccade or smooth pursuit. RT-PCR analysis showed that transcript level of ZmCPK11 in maize leaves increased in response to PA treatment.

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The objective of this consensus statement is to propose a diagnostic and management approach for acute PE in India. Nucleus accumbens hyperpolarization-activated cyclic nucleotide-gated channels modulate methamphetamine self-administration in rats.

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Among the high points of immunological discovery has been the identification of antigen-recognizing receptors on B and T cells. In case 1, the patient started weeping immediately after the first treatment. Because all of the tumors had been well differentiated adenocarcinoma, 21 cases of well differentiated adenocarcinoma which had metastasized to both the lung and other distant organs were selected as controls. Therefore, the essential carboxyl group is assumed to play an important role in the interfacial activation. Oritavancin activity against vancomycin-susceptible and vancomycin-resistant Enterococci with molecularly characterized glycopeptide resistance genes recovered from bacteremic patients, 2009-2010.

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Recently, the anti-apoptotic factor Bcl-2 has been reported to also inhibit autophagy, thus establishing a potential link between these pathways, but the mechanistic details are only beginning to emerge. We developed a site-specific method for precipitating inorganic compounds using organic compounds, DNA, and designed peptides with peptide nucleic acids (PNAs). Comparison of donkey hemogram using the LaserCyte hematology analyzer, an impedance system, and a manual method. We used high performance liquid chromatography (HPLC) to measure the concentrations reached by imipenem, a modern wide-spectrum beta-lactam antibiotic, in plasma and aqueous humor of 26 patients scheduled for cataract surgery.

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Mononuclear infiltrates in human intracranial tumors as a prognostic factor. We are thinking of starting a pre-retirement group with the onus on health care and prevention and would like to hear from anyone who has initiated a similar group for information/advice. In addition, mutations in SAM domain and SAM-mediated oligomers have been linked to several diseases. Several microfluidic lab on chip (LOC) technologies have been developed, where mechanical and chemical methods are used for the extraction and purification of nucleic acids. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to normalize their levels.

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Clinical scales, including investigator-rated clinical global impression of improvement (CGI-I), were collected at both visits. A secondary goal was to create regression models using anthropometric data to predict moment arms of the flexor digitorum superficialis about the metacarpophalangeal joint of each finger.

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Nurses are being put on the dole at a time when more people need nursing care as the recession takes its toll, RCN General Secretary Christine Hancock has told a conference. It is generally believed that continuous generation of intracellular reactive oxygen species (ROS) during oxidative phosphorylation (OXPHOS) is a major underlying mechanism for generation of such mtDNA deletions while antioxidant systems, including Manganese superoxide dismutase (MnSOD), mitigating the deleterious effects of ROS.

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It describes the biopsy technique, possible complications and rules for post-biopsy monitoring of benign lesions. Use of some quantitative electrocardiogram criteria in ventricular hypertrophy diagnosis. The mechanisms of lymphangion interaction in the process of lymph movement Dose-Fractionation Schedules for Radiotherapy of Bone Metastases. Study participants completed a questionnaire on reproductive and lifestyle factors in 1996-2001, and were followed for cancer and death via national registries.

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The aim of this study was to evaluate the effect of an in-office carbamide peroxide-based tooth bleaching agent on the wear resistance of a silorane-based and a conventional microhybrid dimethyl methacrylate-based dental composite with two different application times. Herein, an unprecedented visible-light-induced hydrodifluoromethylation of alkenes with bromodifluoromethylphosphonium bromide using H2O and THF as hydrogen sources for the synthesis of difluoromethylated alkanes is described. Indeed, the survival rate for patients treated with PD is now equivalent to that with in-center hemodialysis.

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Blastogenesis in cultures stimulated with either concanavalin A (Con A) or pokeweed mitogen (PWM) was inhibited in the presence of the supernate, as was the response to purified protein derivative in lymphocytes from BCG-vaccinated cattle. Organization and chemical neuroanatomy of the African elephant (Loxodonta africana) hippocampus.

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The analysis of the frequency spectra indicated that the power increase occurs expecially in the higher frequencies of the EEG signal. THE EFFECTS OF MYELIN ON THE DEMONSTRATION OF AUTONOMIC FIBERS AND CEREBROSPINAL AXONS OF PERIPHERAL NERVES The interrelationship between promoter strength, gene expression, and growth rate. A knowledge base for predicting protein localization sites in eukaryotic cells. A common in vitro method to study Staphylococcus epidermidis biofilm development is to allow the bacteria to attach and grow on a solid surface in the presence of a continuous flow of nutrients.

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Our results would suggest that oxprenolol has the property of unmasking or revealing alpha receptors responsible for the excitatory effects of adrenaline upon isolated strips of human colon. Arsenic removal from drinking water by a household sand filter in Vietnam--effect of filter usage practices on arsenic removal efficiency and microbiological water quality. THE SIGNIFICANCE OF SUBCORTICAL MOTIVATIONAL MECHANISMS IN THE ORGANIZATION OF CONDITIONAL CONNECTIONS. Multiple logistic regression analysis of the Social Network Index results indicated statistically significant positive associations of social support with the use of mammography and occult blood stool examination but not with the other cancer-screening tests. The role of the hypothalamus and sympathetic nervous system in regulation of the investigated enzymes of energy metabolism in the liver is discussed.

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Patients with RAO and AION have a significantly decreased RCF in comparison with controls. All thyroid cancer recurrences were operatively managed, and local recurrences in cervical lymph nodes or cervical soft tissue were histologically confirmed. Physiological and psychological measures indicate that FSI may be experiencing symptoms and changes to their health consistent with an overtraining type condition. Retinopathy of prematurity (ROP) is a potentially blinding vasoproliferative disease. We investigated a protein profile evolution during steatosis in ducks using 2-dimensional electrophoresis gels to better understand the mechanisms underlying liver steatosis at the level of hepatic proteins in waterfowl.

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Effect of cold stress on performance and immune responses of Bedouin and White Leghorn hens. Governance and Standards in International Clinical Research: The Role of Transnational Consortia. In patients affected by severe RLS, pharmacological treatment is mandatory. Genome Sequencing and Analysis of Catopsilia pomona nucleopolyhedrovirus: A Distinct Species in Group I Alphabaculovirus.

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Lung tissues from the offspring were examined through Western blotting, immunohistochemistry, and morphometry on Postnatal Day 3 and Postnatal Day 7. Although the type I reaction has been used with great success, the molecular scaffolds accessible by the type II reactions are limited by the strain inherent in the formation of an sp(2) carbon at a bridgehead position. During later limb bud stages, Ezh2 is essential for cell survival and proximodistal segment elongation.

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This paper presents the standards of thyroid ultrasound examination regarding ultrasound apparatus technical requirements, scanning techniques, readings, measurements, and the description of the examination. It is very rare with only 22 case reports describing 24 children including four sibling pairs.

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Peptides were visible in the oral secretion stimulated by the various drugs after separation and staining in SDS-polyacrylamide gels. Symptomatic limbs in children with an MMC showed increased knee flexion and trends toward higher extension, adduction, and internal rotation moments.

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The expertise of the rheumatologist has widened such that knowledge of economics, legal issues, related disorders and extraarticular disease is essential. Five patients were considered progression-free after 12 weeks, prompting continuation of the trial. In this nationwide cohort, psoriasis was associated with a disease severity-dependent increased risk of sarcoidosis.

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Applications of fluorescent semiconductor nanocrystals in microscopy and cytometry The pattern of field changes was an increasingly severe, uniform depression. Significant differences are present between the dimensions of the upper and lower dental arches in Class II division 1 malocclusion (with a mandibular deficiency and in the permanent dentition) compared to normal Class I occlusion dental arches.

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Effects of NBM lesions with two neurotoxins on spatial memory and autoshaping. Elucidating asthma phenotypes and endotypes: progress towards personalized medicine. QoL was found to be higher with an AC compared with BT injections.

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The Code of Medical Ethics (CME) of the Federal Council of Medicine is the legal document that exposes the moral discourse of Brazilian physicians to society and the profession. To investigate the timing and dosage of topical corticosteroid use after keratoplasty for fungal keratitis, and to evaluate the results with regard to anterior segment inflammation, immune rejection, and fungal recurrence. The most pertinent areas to invoke vicarious trauma in research have been suggested as abuse/violence and death/dying. The data suggest that memory expression depends on non-NMDA receptor-mediated mechanisms, perhaps the expression of LTP, up to at least 20 days after acquisition.

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Because mice provide a powerful mammalian platform for modeling complex disease, this paper focuses on mouse models of exfoliation syndrome and exfoliation glaucoma. These findings demonstrate that Nur77 is a novel negative regulator of ET-1 expression in vascular ECs through an inhibitory interaction with the c-Jun/AP-1 pathway. Correction of urinary stress incontinence: use of urethral lengthening with full thickness anterior colporrhapy.

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Lower SES was linked to higher obesity risk in both Paris and Seattle, despite differences in urban form, the food environments and in the respective systems of health care. The gene encoding m-hydroxybenzoate hydroxylase (mobA) was cloned from Comamonas testosteroni GZ39. Are these fewer difficulties and risks in early excision-graft than in the slower methods?

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Plasmodium infection during gestation may lead to severe clinical manifestations including abortion, stillbirth, intrauterine growth retardation, and low birth weight. In conclusion, a U-Ca/Cr ratio of less than 0.1 (mg/mg) in VDDR1A patients is useful to accurately evaluate calcium depletion and secondary hyperparathyroidism. When making these estimates it may be necessary to extrapolate from relatively limited laboratory data to the real world. A mutation in the nadB gene, encoding L-aspartate oxidase, was shown to be responsible for the nicotinamide requirement of UTI89.

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The mediating role of anger in the relationship between automatic thoughts and physical aggression in adolescents Finally, we classified a sample of 120 female volunteers into ten clusters exhibiting different skin properties according to their genotypic signature. Hemopoietic neoplasms in lethally irradiated mice repopulated with bone marrow cells carrying the human c-myc oncogene: a repopulation assay.

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The signs, clinical course and lesions of the experimentally induced disease were comparable to those of field cases. The amount of saturated fatty acids in plastidial membrane lipids increased.

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Cement remnants at the submucosal area can be detected in some cases, which can be helpful in preventing peri-implant diseases. This process relies on various morphological changes that are driven by dynamic cytoskeleton remodelings. We are not aware of any other cases of myocardial abscess rupture in this location of the heart, in a patient of this age, or due to infection with community-associated methicillin-resistant S aureus .

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Researchers, animal rights activists fight public relations war at Western. Comparative analysis of antemortem and postmortem dental records excluded identification, while the results of superimposition (simultaneously performed by another team member) revealed sufficient concordant points to establish identity. Many pollutants released into the environment as a result of human activities are chiral.

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The structure of acacetin-7-rutinoside was elucidated based on spectral data, including 1H NMR and 13C NMR. Type IV pili (Tfp) are surface-exposed filaments playing a key role in pathogenesis in a variety of bacterial species, including N. There were no significant adverse events in any patient, and all but one patient remained on methadone until the time of their death. Although this process exerts positive effects on axonal regeneration, excessive astrogliosis imparts negative effects on neuronal repair and recovery. More clinical studies have to be conducted to evaluate therapeutical methods that might ameliorate cutaneous oxygen saturation within diabetic foot disease and PAOD.

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This method may be useful in terms of easiness and security of suture. Optimization of culture conditions for high cell density proliferation of HL-60 human promyelocytic leukemia cells.

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L-Glutamate (Glu) homeostasis in brain extracellular pantoprazole iv nursing considerations for vancomycin fluids and its maintenance at low micromolar concentrations in the face of the extremely high Glu concentrations present in brain cells and synaptic vesicles have been commonly attributed to the very effective action of glutamate transporters present on neuronal and glial cells. Its diagnosis can be further complicated when patients initially present with acute SAH.

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Emergency balloon iv acyclovir prophylaxis occlusion for massive epistaxis due to traumatic carotid-cavernous aneurysm. We sought to investigate the efficacy and safety of peanut oral immunotherapy using CpG-coated poly(lactic-co-glycolic acid) nanoparticles containing peanut extract (CpG/PN-NPs) in a murine model of peanut allergy.

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We identified a zinc finger transcription factor, Smed-ZicA, as a downstream target of Smed-FoxD, a Forkhead transcription factor required for head regeneration. SPIA could determine cysC levels that detected early renal impairment. HGV is a cutaneous vasculitis, related to a benign B-cell proliferation, whereas CV is a systemic immune complex-mediated vasculitis with complement activation and a higher risk of lymphoma, thus confirming CV but not HGV as a prelymphomatous condition in pSS. As 3 of the 5 HIV-associated TEN cases were caused by potentially inappropriate or unnecessary use nidazole 500 mg metronidazole of antibiotics, our experience highlights the importance of judicious use of systemic medications in populations susceptible to severe adverse drug reactions. Alternative products and methods used instead of immunotherapy are tea therapy, acupuncture, Nigella sativa, cinnamon bark, Spanish needle, acerola, capsaicin (Capsicum annum), allergen-absorbing ointment, and cellulose powder.

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Chronic rhinosinusitis with nasal polyposis (CRSwNP) in Western countries is characterized by eosinophilia, IgE production, and TH2 cytokine expression. Leucocyte and plasma ascorbic acid values were measured in healthy students, adult factory employees, and old people not receiving supplementary vitamin C and in healthy old people receiving 500 mg of vitamin C depsonil uses daily. Thus the developing chloroplasts appear to contain all of the enzymatic machinery necessary to convert glutamic acid to Chl via the C5 pathway of ALA formation but the Shemin pathway from succinyl coenzyme A and glycine to ALA appears to be absent.

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Chlorothiazide and electrolyte depletion in chronic glomerulonephritis. Benchmark study rebetron dosage calculator on fine-mode aerosol in a big urban area and relevant doses deposited in the human respiratory tract.