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Apcalis is an oral medication called a phosphodiesterase-5 (PDE5) inhibitor approved for the treatment of pulmonary arterial hypertension (PAH) in World Health Organization (WHO) Group 1 patients. The goal of this therapy is to improve exercise ability and delay clinical worsening. Research studies showing the effectiveness of the medication included mostly patients with symptoms that were rated as WHO Functional Class II-III. Apcalis is marketed as Adcirca for PAH and was approved by the United States Food and Drug Administration (FDA) in 2009. Apcalis is also marketed as Apcalis for erectile dysfunction but not for the treatment of PAH.

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