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CLAP is a useful protein-clustering tool, independent of domain assignment, domain order, sequence length and domain diversity. Hip and pelvis range of motion and vertical ground reaction force were evaluated using the Qualysis motion analyzer system and a Kistler force plate.

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One of the most striking examples of this role is that of the spectrin-free spherocyte mouse. Children with SLI showed atypical errors in the comprehension test at the age of 4, but presented a pattern of errors that gradually resembled typical development. Different published results indicate that CDK1 activity is either important or dispensable for the cytotoxicity associated with spindle disruption. Finally, we propose a new systems pharmacology method, which is further applied to an integrated platform (Herbal medicine Systems Pharmacology) of blended herbal medicine and omics data sets, allowing for the systematization of current and traditional knowledge of herbal medicines and, importantly, for the application of this emerging body of knowledge to the development of new drugs for complex human diseases. At discharge on day 24, the infant had improved state regulation, behavioral organization, and motor performance.

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Tolerance to beta 2-agonists in patients with chronic obstructive pulmonary disease. It is therefore important to reinforce health education and screening services among such high risk populations. Radiofrequency identification (RFID) detection systems are used to detect retained surgical sponges and may cause electromagnetic interference (EMI), altering intended function of cardiac pacing systems.

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Both GH and PRL levels remained suppressed during a 6 day course of treatmnt with metergoline. The rapid growth of the global HIV/AIDS epidemic makes it a high priority to develop an effective vaccine. A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine. Although much attention has been focused on the association between chronic hyperglycemia and cerebrovascular diseases in type 2 diabetes mellitus (DM) patients, there is no data regarding the risk of ischemic stroke after a hyperosmolar hyperglycemic state (HHS) attack.

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Serum proteomics analysis and comparisons using iTRAQ in the progression of hepatitis B. They also reflect stimulus-specific influences that must be considered when testing hypotheses about modality-specific deficits in sustained attention in populations with different developmental disorders. Electromyographic findings in lower extremities of patients with traumatic quadriplegia.

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Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Expression and ligand-binding function of the integrin alpha 4 beta 1 (VLA-4) on neural-crest-derived tumor cell lines.

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Traffic air pollution in Kuwait: preliminary results for nitrogen oxides and carbon monoxide. Mitoxantrone fluorescence intensity is altered by pH and the emission spectrum is red-shifted by DNA. After 7 days of co-culture the concentration of the mRNAs was increased 12-15-fold by phenobarbital. Intravitreal bevacizumab (Avastin) for the treatment of proliferative sickle retinopathy.

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Truncation of the N-terminal tail to residue 46 demonstrates that this region is not critical to bilin attachment, but a deletion mutant lacking 222 amino acids from the N terminus failed to yield holophytochrome in vitro, under the same conditions. Transoral surgical approach for treatment of symptomatic atlantoaxial cervical synovial cysts. Affiliation to the nomadic Datoga tribe and lack of vaccines determine VRs in this rural population. Osteonecrosis of the jaw (ONJ) following bisphosphonate use is well documented.

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In this report, we describe the in vitro and in vivo characterization of novel inhibitors of LpxC, an enzyme whose activity is required for proper lipid A biosynthesis, and demonstrate that our lead compound has the requisite attributes to warrant further consideration as a novel antibiotic. The postoperative aspiratory draining is useful for the favourable evolution of the wound. Tools to obtain skin cell release for cytofluorimetric analyses are, therefore, very useful in order to study the complex network of immune cells residing in the skin and their response to microbial stimuli. Computational prediction of microRNA (miRNA) targets is a fundamental step towards the characterization of miRNA function and the understanding of their role in disease.

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Although toxic mastitis has a poor prognosis in domestic sows, this babirusa recovered completely with aggressive management, including antibiotics and supportive care. The mean operative time was 206.6 min (range, 120-280 min), the mean estimated blood loss was 122.2 cc (range, 25-350 cc), and the mean admission time was 3.3 d (range, 1-7 d). Further, it can be repeated and hence, is useful in evaluating the response to treatment. QY is also low when both the N-terminal amine and indole amine are deprotonated. It has been demonstrated that such unusual behavior is commonly seen for two types of rodlike molecules as well as for various mixture compositions.

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Il-2-induced cell proliferation was also noted in syngeneic MLR, but did not lead to GVHD in in vivo experiments. We have shown that increasing ROS levels or oxidative damage does not necessarily lead to decreased lifespan.

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Three restriction fragment length polymorphisms (RFLPs) (MspI, PstI, ScrFI/BstNI) within the human porphobilinogen deaminase (PBG-D) gene have been studied in 47 unrelated patients with the autosomal dominant disorder, acute intermittent porphyria (AIP), and in 92 control subjects. Lowering plasma free fatty acid levels improves insulin action in conscious pregnant rabbits.

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Fifteen Royal College of Physicians and Surgeons of Canada (RCPSC) ophthalmology residency program directors. Degradation of organic matter from domestic wastewater with loofah sponge biofilm reactor. Plasma Fstl1 levels were measured by enzyme-linked immunosorbent assay.

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Findings are consistent with a causal role of sexual behavior in the acquisition of BV and confirm that BV facilitates acquisition of gonorrhea/chlamydia and vice versa independently from other risk factors. The two products of Aspergillus strain M39 appear to reverse multi-drug resistance by interacting with P-glycoprotein and inhibiting its role as an active efflux pump. Typhoid fever is a severe febrile illness caused by Salmonella typhi. Clinical observations and results of animal experiments suggest that these seizures might originate from the mesencephalic reticular formation.

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Our findings over an 8-year period suggest that unrecognized functional or organic retention disorders are present in encopresis more often than previously thought. Primary limbal epithelial cells (LECs) in the form of single cell suspension or cell clusters were cocultured on a monolayer of either 3T3 cells (control) or LMCs (SC-LMC culture). Pregnancy after bone marrow transplantation for severe aplastic anemia.

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Furthermore, a close interaction between verapamil and the dopamine receptors might partially explain the central effects of verapamil. The frequency and severity of CNSLD was studied in workers of an Hungarian firm (Ganz-Mavag) by means of questionnaire. Psychological Characteristics in Acute Mild Traumatic Brain Injury: An MMPI-2 Study.

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Despite widespread interest in adolescent smoking behavior, little research has been directed to the social dynamics of adolescent smoking. Genetic investigation was performed to identify the underlying mutations. Analysis and evaluation of S-phenylmercapturic acid as a biomarker for benzene exposure

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vivax, Wuchereria bancrofti, Toxoplasma gondii, Taenia solium, and Strongyloides stercoralis. Although reanalyzing large national survey datasets is an expedient and cost-efficient way of producing nursing knowledge, successful investigations require a methodological consideration of the intrinsic limitations of secondary survey analysis. Association between NOS3 genetic variants and coronary artery disease in the Han population. Although various ISC signature genes were also identified as CRC markers and some of these genes were even demonstrated to have a direct functional role in CRC development, the origin of CSCs and their contribution to cancer progression is still debated. There needs to be greater attention in both policy and practice to the purposes and alignment of the three approaches if they are to embed a system-wide focus that supports quality improvement at the service level.

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In this article, the advantages of recognizing the developmental cycles of drug epidemics are outlined, the most important of which concerns the future. Inhaler technique in hospitalized Saudi patients was inadequate. Academization of naturopathy and complementary medicine in the German language area We prospectively enrolled 232 consecutive patients who underwent arthroplasty or total replacement of the knee joint for treatment of OA. Ten metabolites were identified with nLC-MS/MS, including those detected by MALDI IMS.

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No difference in the haemodynamic parameter at rest was noted in the transferred group for moderate hypertension and the non-transferred group. In particular, we asked whether individual differences in capacity remain consistent if capacity is shifted by a more demanding task, and, further, whether the correspondence between behavioral and neural measures holds across a shift in VWM capacity. The relative levels of transcripts from individual members of the CHS multigene family differed significantly at 1.5 h compared to 22.5 h after elicitation. Tenotomy immobilization as a model to investigate skeletal muscle fibrosis (with emphasis on Secreted frizzled-related protein 2). States of curiosity modulate hippocampus-dependent learning via the dopaminergic circuit.

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Diagnostic accuracy of 2 oral fluid-based tests for HIV surveillance in Namibia. Taken together, our results show that these Vegfr2 regulatory elements are active during adult neovessel formation in general. We demonstrate that all RGM-NEO1 complexes share this architecture, which therefore represents the core of multiple signaling pathways.

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Age-specific mortality due to HCC was gleaned from people aged 20-84 years during 1940 through 2010 in Japan. In a murine model, overexpression of NCoA2 in the prostate epithelium resulted in neoplasia and, in combination with Pten deletion, promoted the development of metastasis-prone cancer. Cardiac rehabilitation (CR) participation is associated with significantly lower mortality, and this benefit has been established as dose-dependent. 1.3 mm(3) resolution data acquired with the 32-channel coil provided higher image- and temporal SNR and yielded higher BOLD sensitivity measures, notably higher cluster sizes in MI/SI and increased z-scores, though not an increase in percent signal change.

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The study employed a prospective case-control design in which control cases were randomly selected from a large Army installation at a rate of four control participants for every qualifying Army suicide. Type IV(B) pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner. Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial. Changes in cardiac output and peripheral flows on pentobarbital anesthesia in the rat. So the role of CT component in elucidating three embryonal components and hypermetabolism evident on PET part suggesting possible malignant transformation makes PET/CT a valuable modality in evaluation of these rare tumors.

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Of particular interest are recombinant human proteins expressed in plant-based systems, which have shown particularly high CM variability. Host miRNA degradation by Herpesvirus saimiri small nuclear RNA requires an unstructured interacting region. Editorial: The learning curve in surgical randomized controlled trials. Cochran-Mantel-Harnszel (CMH) testing and chi-square analysis were used to detect any associations or relationships between variables within the database. Improved semiautomated method for assay of phosphorus in serum phospholipids.

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Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. We identified all RCTs of inhaled long-acting bronchodilator therapy, during 1999-2013, at ClinicalTrials.gov and translated trial selection criteria into definitions compatible with electronic medical records. Accordingly, their spatiotemporal dynamics are tightly regulated. Oral active androgens or anabolic steroids when given in doses needed to inhibit spermatogenesis are liver toxic.

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Until recently, the major contributing pathophysiological event thought to initiate migraine was cerebral and meningeal arterial vasodilation. DEVELOPMENT OF THE QUADRIVALENT LIVE ATTENUATED INFLUENZA VACCINE INCLUDING TWO INFLUENZA B LINEAGES--VICTORIA AND YAMAGATA One-year changes in workplace staffing levels were obtained from Statistics Finland records on workplaces.

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Low expression of human equilibrative nucleoside transporter-1 (hENT1) may result in gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). In an effort to increase iron nutrition, we report here the transgene introgression of a high-iron trait into a high-yielding indica rice cultivar. MLL fusion genes are also capable of recruiting DNA methyltransferases at microRNAs promoters controlling their expression through epigenetic changes. This unit describes T cell enrichment using cytotoxic antibodies, and UNIT 3.4 describes the depletion of T cells and their subpopulations using the same approach.

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In four of eleven patients, reentry was prevented despite achieving the so-called critical atrioventricular nodal delays that had previously caused reentry during control study. Clinical perception and simple laboratory tests: do not mistake the finger pointing at the moon. Ki67 may be an effective pharmacodynamic biomarker to identify response early in the course of treatment. Even though the resulting field of view is limit by the aperture size, row-column addressed arrays and the row-column addressing scheme can be an alternative option of 2-D arrays for NDT applications. Inhalation of hot fumes may cause upper respiratory tract oedema (e.g.

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This unit includes the complete set of protocols needed to generate recombinant adenoviruses using the AdEasy system. On the other hand, trials addressing the prevention of the first-ever fracture are still needed for children who have both a high likelihood of developing fractures and less potential for recovery. Inhibition of uPAR expression by antisense oligonucleotides promoted caveolae disruption, suggesting that uPAR is an inducer of caveolae organization. In this study, 570 lesions from 527 consecutive patients who had both baseline Pd/Pa and FFR determined were evaluated retrospectively. The animals were examined clinically daily for 20 days for the feline respiratory disease complex.

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The acquisition of these skills necessitates a combination of exposure to clinical pathology, hands-on US training, and feedback. Sandwiches are major contributors of sodium in the diets of American adults: results from What We Eat in America, National Health and Nutrition Examination Survey 2009-2010.

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The recellularized scaffolds did not reach high cell densities comparable with the former systems but supported well cell anchorage and migration without any signs of cell regression. Herpetic encephalitis (HSE) is caused mainly by herpes simplex virus type 1 (HSV-1) with an annual incidence of 1-4 cases/million inhabitants. The Canadian Consensus Working Group provides a structured framework for avoiding, evaluating and managing goal-inhibiting statin intolerance.

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Sport shoes affect the pattern of movement in a way that is unsafe. Bony fish primarily excrete ammonia as adults however the persistence of urea cycle genes may reflect a beneficial role for urea production during embryonic stages in protecting the embryo from toxic effects of ammonia produced from a highly nitrogenous yolk. The effect of elevated fetal hemoglobin on hemoglobin A1c results: five common hemoglobin A1c methods compared with the IFCC reference method.

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Anthocyanoplasts were usually in the vacuole, although sometimes in the cytoplasm, of the mung bean and cabbage, but were never seen in vacuoles of Prunus callus. Examination of the discrepancy between size estimates for ovalbumin from small-angle X-ray scattering and other physicochemical measurements. The current data suggest that survival of patients with Morquio syndrome A in the UK has improved in recent decades. Effect of an ultra-high frequency field on the physical trainability of experimental animals All bundles contained interventions that were either professional, organizational or a mixture of both.