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Endoxana (Cyclophosphamide)
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Cyclophosphamide

Endoxana is a drug that is used primarily for treating several types of cancer. In order to work, Endoxana first is converted by the liver into two chemicals, acrolein and phosphoramide. Acrolein and phosphoramide are the active compounds, and they slow the growth of cancer cells by interfering with the actions of deoxyribonucleic acid (DNA) within the cancerous cells. Unfortunately, normal cells also are affected, and this results in serious side effects. In addition to slowing the growth of cancerous cells, Endoxana also suppresses the immune system and is referred to as immunosuppressive. The FDA approved Endoxana in November 1959.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Comparative effectiveness of novel oral anticoagulants for atrial fibrillation: evidence from pair-wise and warfarin-controlled network meta-analyses. The clinico-diagnostic complex included radiography of the spine (round-up and functional), magnetic resonance imaging, computerized helical tomography of the spine with spondylometric measurements.

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The potential role of custody facilities in controlling sexually transmitted diseases. This review will focus on the tumor immune microenvironment, the expression of PD-1/PD-L1 and the effect of immune modulation using PD-1 or PD-L1 inhibitors in patients with head and neck, prostate, urothelial, renal, breast, gastrointestinal and lung cancers. This is of fundamental importance if we are to understand, and perhaps reverse, the high rate seen in Western countries.

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The aim of the study is to evaluate morphological and biological tumor parameters to identify new expanded criteria for the selection of patients with HCC as candidates for LT. c-Jun N-terminal kinase-2 (JNK2) exhibits both tumor promoter and tumor suppressor actions, depending on tumor type. Effective communication is fundamental to successful health care service delivery, and has a positive impact on access, quality of care, health outcomes, and patient satisfaction. Estimating epidemiological parameters for bovine tuberculosis in British cattle using a Bayesian partial-likelihood approach. Insecticide resistance and diminished secondary kill performance of bait formulations against German cockroaches (Dictyoptera: Blattellidae).

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Patients with advanced cancer frequently experience clinically significant anemia, which is often exacerbated by myelosuppressive chemotherapy. Thus, a granuloma that persists despite repeated treatment may be a possible sign of asymptomatic internal malignancy. Study of Deaths by Suicide in the Soviet Special Camp Number 7 (Sachsenhausen), 1945-1950. Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors.

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At ten-day intervals, blood concentrations of glucose, lactate, pyruvate and urea were measured, as well as when clinical signs of PEM appeared. The purposes of this present research were, in the first study, to determine whether age impacts a measure of postural control (the braking force in walking) and, in a second study, to determine whether exergame training in physically-simulated sport activity would show transfer, increasing the braking force in walking and also improving balance assessed by clinical measures, functional fitness, and health-related quality of life in older adults. An increasing number of human immunodeficiency virus-1 (HIV-l)-discordant couples in Taiwan have been seeking fertility help.

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Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice. The method for the assay of glutamine synthetase (GlnS) relies on the gamma-glutamyl transferase reaction, i.e.

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More sophisticated approaches will likely require multimodal techniques, both by enhancing immunity, but also geared towards overcoming innate mechanisms of immunosuppression that favor tumorigenesis. To determine whether selection of genome segments in coinfections is strain-specific, chicken embryo fibroblasts were coinfected with avian reovirus strain 883 and one of three other avian reovirus strains (176, S1133 and 81-5). Robot-Assisted Posterior C1-2 Transarticular Screw Fixation for Atlantoaxial Instability: A Case Report. She had always lived in a rural area, located in the humid subtropical forest.

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The cytotoxic lymphocytes obtained after 7 days of culture were tested for their ability to kill autochthonous leukaemic cells in a 3h 51Cr-release assay. Furthermore, TaGID2s interact with most RHT-1s, such as RHT-B1h, RHT-B1i, RHT-D1e, RHT-D1f, etc., but cannot interact with RHT-B1b or RHT-B1e, which have a stop codon in the DELLA motif, resulting in a lack of a GRAS domain. Systolic descent of the tricuspid anulus (i.e., total excursion of tricuspid anulus during systole) was also measured using echocardiography. The Author after having examined the present acquirements of the native enzymes of the grapes, summarizes the enologic uses of the enzyme preparations at various degrees of purity with the point of view of the influence on the organoleptic (color, aromatic composition) ad rheologic (yield, filtrability) characteristics of the musts and wines besides some microbiological implications. To better define the population of adolescents who request and use EC pills, we performed a post hoc analysis of an over-the-counter simulation study of EC pills.

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Propionyl-L-carnitine limits chronic ventricular dilation after myocardial infarction in rats. Incidence rate of falls and its risk factors in patients with rheumatoid arthritis compared to controls: Four years of the TOMORROW study. Aqueous solutions of charged spherical macroions with variable dielectric permittivity and their associated counterions are examined within the cell model using a field theory and Monte Carlo simulations. Leucocytosis discovered prior to the surgery is a highly specific early death predictor. Localization depends on the topology of the interaction networks, and it positively correlates with the variance of the weighted degree distribution, a signature of the network topological heterogeneity.

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Both the direct effect upon amastigote and trypomastigote forms and the effect upon the interaction of heart muscle cells (HMC) with bloodstream trypomastigotes were studied. This study investigated the mechanical properties of aTAAs compared with normal human ascending aortas for eventual development of biomechanical aTAA risk models. Sensory adaptation has been measured in the antennae of male Grapholita molesta (Busck) after 15 min of exposure to its main pheromone compound (Z)-8-dodecen-1-yl acetate (Z8-12:OAc) at the aerial concentration of 1 ng/m(3) measured in orchards treated with pheromone for mating disruption. The present study investigates the arguments used by university students in order to explain social differences between social minorities and majorities.

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Furthermore, overexpression of klotho had synergistic effects with cisplatin to inhibit the proliferation of drug-resistant lung cancer cells in a dose- and time-dependent manner. Moreover, data from an MCC patient indicate that loss of RB1 rendered the MCPyV-positive MCC cells LT independent. Common hereditary neurodevelopmental disorders such as autism, bipolar disorder, and schizophrenia are most likely both genetically multifactorial and heterogeneous. Effect of acute temperature change in some renal functions in sickle cell disease. Uninfected urine usually contained less than or equal to 10(3) WBCs per milliliter, although up to 8 X 10(3) WBCs per milliliter were observed.

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ASPC-1 and HPAC cell lines were tested for sensitivity to ganetespib, 5-fluorouracil/oxaliplatin, and gemcitabine/paclitaxel, alone and in combination, using an in vivo tumour xenograft model. Early mobilization may reduce complications and confer benefit for children with respiratory failure or those who require prolonged mechanical ventilator support. Patients in the single-deposit group had an injection through a catheter parallel to the median nerve. We sought to evaluate the prescribing pattern of statins according to national and regional health policy interventions and to assess specifically the adherence to the therapy in outpatient setting in Southern Italy.

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PTP significantly increased following the laryngeal dehydration challenge. In this study, using comparative genomics, we report identification of 3,942 R. Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy. Organized youth sports have an important role in improving and maintaining a favorable sense of self-worth, reducing anxiety, and promoting productive coping strategies in adolescents when dealing with everyday problems. Epidemiology of globus symptoms and associated psychological factors in China.

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Evaluation of cre recombinase delivery in mammalian cells using baculovirus infection. TRANSMEMBRANE ELECTRICAL ACTIVITY OF PULSATILE VESICLES DIFFERENTIATED IN ORGAN-TYPE CULTURE BY FRAGMENTS OF CHICK EMBRYO PRECARDIAC AREA

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Treatment of patients with generalized large uveal melanoma with extrascleral extension is difficult. All women were examined clinically and sonographically during the follow-up appointments at weekly intervals for up to 4 weeks as appropriate. As recently shown, evidence is now accumulating that anti-dsDNA antibodies are most likely germline-encoded and antigen-selected, as demonstrated by sequence analysis of human anti-dsDNA antibody clones from SLE patients. To investigate and analyze the typical CT findings of salivary gland lymphoepithelial carcinoma. On-Farm Evaluation of Hermetic Technology Against Maize Storage Pests in Kenya.

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Molecular design, structural analysis and bactericidal activity of derivatives of antimicrobial peptide buforin II Receptor-recycling model of clearance and distribution of insulin in the perfused mouse liver.

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Target-dependent induction of secretory capabilities in an identified motoneuron during synaptogenesis. Evisceration itself is not a cause for increased mortality or cardiovascular instability seen in the ER. Poster 397 Noninvasive Treatment of Cervical Muscle Spasm After Cervical Laminectomy and Fusion: Osteopathic Manipulative Therapy in Acute Rehab: A Case Report.

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Revision knee arthroplasty for bone loss: choosing the right degree of constraint. - Acute pulmonary injury is a significant cause of morbidity and mortality.

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Previously described methods for gene transfer into the arterial wall require total vessel occlusion for 30 minutes. In pain therapy neurostimulation procedures have replaced the previously used lesional methods with only very few exceptions. The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events. To study the association of air pollution with health service demand of the elderly and middle-age patients with cardiovascular and cerebrovascular diseases, and to provide a scientific basis for development of environmental protection policy and health service policy of the Chinese government.

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Infection with Wuchereria bancrofti did not appear to affect the survival of the mosquito. In an in vivo investigation, rats were intraperitoneally (i.p.) administered with Dox to duplicate the model of Dox-induced chronic cardiotoxicity. Sleep organization and energy expenditure of breast-fed and formula-fed infants. Patients with spina bifida present with bladder cancer at an atypically young age with very advanced disease. Development of GCxGC/TOF-MS metabolomics for use in ecotoxicological studies with invertebrates.

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Results showed that combining predictive information in pre- and post-stimulus brain activities can achieve significantly better performance in classifying high-pain and low-pain and in predicting the rating of perceived pain than only using post-stimulus brain activities. These determinations are simple, noninvasive, and can be accomplished within minutes. The inhibition of the Src/PI3K pathway significantly suppressed LPLI-induced actin polymerization and phagocytosis enhancement. Furthermore, olfactory receptors that detect cadaverine and putrescine have not been identified in any species so far.

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The characterization of the pathway of maltose utilization by Escherichia coli. The trend towards personalized medicine and the long-standing wish to reduce drug consumption and unwanted side effects have been the driving force behind research on drug delivery vehicles that control localization, timing and dose of released cargo. at Tohoku University led to the simultaneous and totally independent discovery of phytoecdysteroids.

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ECM Composition and Rheology Regulate Growth, Motility, and Response to Photodynamic Therapy in 3D Models of Pancreatic Ductal Adenocarcinoma. The results support the hypothesis that individuals with chronic pain display specific attentional biases toward pain-related stimuli and demonstrate the value of eye-tracking technology in measuring differences in visual attention variables. However, iPSCs could not be maintained without ectopic expression of transgenes. The simulation package allowed for the separation of both coherent and incoherent single scatter.

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THE STANDARD PODIATRIC NOMENCLATURE OF DISEASES AND OPERATIONS AND THE REPORTING OF HEALTH SERVICES. It is probable that the supersensitive responses to ATP and serotonin, observed in the aged rat bladders, may contribute to the development of unstable bladder in elderly people. In some breast cancer cases and breast cancer cell lines, ESR1 expression was not regulated by DNA methylation at T-DMR as it is in normal tissues. Twenty-four ultrahigh risk, 21 patients with schizophrenia and 28 healthy controls were evaluated. Evidence from this study contributes to the nursing science and has implications to nursing practice.

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After treatment with the last-named solutions there was evident a considerable increase of Mg-values in the blood serum for a longer period (up to 6 h), also in the case of distinct hypomagnesaemia while Ca-values of the circulating blood declined more quickly. Our findings suggest that the concentration abnormalities could be related to the substitution fluid for Cs, Rb, Se and Zn and to the dialysate for Mo and Rb. Absence of pharmacokinetic and pharmacodynamic interactions between almorexant and warfarin in healthy subjects.

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In two cases subjected to surgery, the recording electrode left in place at the level associated with the largest killed end potential was found to be located at, or a few millimeters below, the center of the lesions. Further evaluation is needed to access its advantage and reliabilities. Little has been achieved by patient controlled analgesia in the treatment of chronic pain. Heat-induced denaturation of myoglobin, responsible for the characteristic dull-brown color of cooked meats, is influenced by a multitude of endogenous (i.e., pH, muscle source, species, redox state) and exogenous (i.e., packaging, ingredients, storage) factors.

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Besides this primary information, CancerPPD stores predicted tertiary structures as well as peptide sequences in SMILES format. The study was carried out by means of anonymous questionnaires among university students aged 19-24. MTR A2756G, MTRR A66G, and MTHFR C677T polymorphisms may be related to NSCL/P, and interactions were detected between the MTR A2756G, MTRR A66G, and MTHFR C677T and A1298C polymorphisms. To investigate the effect of culture supernatant of Toxoplasma gondii on the proliferation and Toxoplasma gondii tachyzoites with seed counts of 2 x 10(7)/ml, apoptosis of human gastric cancer BGC-823 cells. At a median follow-up of 48 months, the median survival has not been reached.

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Reversible photoswitching specifically responds to mercury(II) ions: the gated photochromism of bis(dithiazole)ethene. Patients in the DiaC were provided with greater consultation times, more frequent clinic appointments and more frequent lifestyle advice than patients prosteride vs propecia before and after in the CDC. Twenty-six newly diagnosed glioma patients underwent 3T-MR DCE and DSC imaging.

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Coupling of carbon monoxide with nitrogen monoxide was achieved at a frustrated Lewis pair template. This study highlights that the differences in size/geometry and thermal properties of small clindamycin 300 mg capsule per capsule wardrobe molecular dopants can have a significant impact on their diffusion in organic device architectures. Further studies on a larger amount of ataxic horses are also required before considering this technique as an alternative option for CSF puncture. Gelatin functionalized graphene oxide for mineralization of hydroxyapatite: biomimetic and in vitro evaluation. Propofol (1.0mg/kg/min) was administered intravenously for 1h before the induction of ischemia.

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The updated recommendations in this policy statement reflect new information regarding the seasonality of RSV circulation, palivizumab pharmacokinetics, the changing incidence of bronchiolitis hospitalizations, the effect of gestational age and other risk factors on RSV hospitalization rates, the mortality of children hospitalized with RSV infection, the effect of prophylaxis on wheezing, and palivizumab-resistant RSV isolates. This report is intended to serve as an introduction to our series of investigations into the role and influence of quality requirements on development lansor tablet fiyat of antibacterial antibiotic products in Japan. Effect of placentotropin and methotraxate on the incubated trophoblast.

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We therefore investigated the significance of the ephrin/Eph signal in IGF-I-induced myogenesis. Secondary sclerosing cholangitis was confirmed by liver biopsy and endoscopic retrograde cholangiopancreatography. After the target is captured, the biotinylated anti-IgE aptamer is alli orlistat 60 mg used as the detection probe. Faculty awards provide an incentive to encourage higher standards of personal performance, which closely reflects the quality of health care.

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A clinical study of artificial tooth roots using composite apatite ceramic implants Furthermore, these significant alterations were investigated with respect to the prognostic value of disease-free survival (DFS) and overall survival (OS). Among a total of 3,074 individuals aged 65 years and over, 2,002 participants were interviewed. A further scoring system was conducted to predict the results of influenza rapid tests and validated in the next 3 weeks. Most discussions of medication risks that we observed were quite limited and often restricted to an assessment of whether the patient was experiencing side apo-norflox 400 mg norfloxacin side effects from their current medications.

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Anatomical studies of the distal popliteal artery and its branches. Rats were allowed to self-stimulate, or underwent gentle handling-induced SDEP (GH-SDEP), during the first 6 h of the light phase, after which they were allowed to sleep. Nucleotide sequence of the fusion and haemagglutinin-neuraminidase glycoprotein genes of Newcastle disease pidocar 75 mg zoloft virus, strain Ulster: molecular basis for variations in pathogenicity between strains.

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Effect of pentosanpolysulfate on experimental kaolin arthritis in the rat paw INDICATIONS FOR THE TECHNIC OF SURGICAL CARE OF VASCULAR INJURIES The structures of the two new compounds were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Monounsaturated fatty acids, olive oil and augmentin duo syrup contains spongy health status: a systematic review and meta-analysis of cohort studies. Liver hernia into the chest cavity through a traumatic diaphragmatic rupture

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gigantica is a foodborne and waterborne zoonotic disease with a worldwide distribution. To what extent can language acquisition be explained in terms of different associative learning mechanisms? The demonstration of OV632 expression provides an important insight into the potential regulatory mechanism governing this tumor marker. Evaluation of persistent diffuse abdominal pain led to clopilet 75 uses the recognition of ductal injury in most patients. The purpose of this study was to investigate exposure levels in a Norwegian swine confinement building, the airway response to such exposure, and to compare invasive and non-invasive methods of response measurement.

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Biodiesel is increasingly considered as an alternative for fossil diesel. Genomic aberrations of retin-a forte clindamycin Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor.