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Esipram (Escitalopram)
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Escitalopram

Esipram is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of major depressive disorder (MDD) and anxiety disorder. This drug exerts a highly selective, potent, and dose-dependent inhibitory effect on the human serotonin transport. By inhibiting the reuptake of serotonin into presynaptic nerve endings, this drug enhances the activity of serotonin in the central nervous system. Esipram also has allosteric activity. Moreover, the possibility of interacting with other drugs is considered low. This review covers randomized, controlled studies that enrolled adult patients with MDD to evaluate the efficacy of Esipram based on the Montgomery–Asberg Depression Rating Scale and the Hamilton Depression Rating Scale. The results showed that Esipram was superior to placebo, and nearly equal or superior to other SSRIs (eg, citalopram, paroxetine, fluoxetine, sertraline) and serotonin-noradrenaline reuptake inhibitors (eg, duloxetine, sustained-release venlafaxine). In addition, with long-term administration, Esipram has shown a preventive effect on MDD relapse and recurrence. Esipram also showed favorable tolerability, and associated adverse events were generally mild and temporary. Discontinuation symptoms were milder with Esipram than with paroxetine. In view of the patient acceptability of Esipram, based on both a meta-analysis and a pooled analysis, this drug was more favorable than other new antidepressants. The findings indicate that Esipram achieved high continuity in antidepressant drug therapy.

Other names for this medication:
Escitalopram, Lexapro, Aramix, Celtium, Cipralex, Citoles, Ectiban, Entact, Esertia, Esipram, Esita, Eslorex, Esram, Gaudium, Lexamil, Lextor, Losiram, Losita, Neozentius, Nexcital, Seroplex, Sipralexa, Tiopram,

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Sulfation of proteins in the primate cerebellum and young rat brain. During the first decade of its marketing, several cases of hyperCKemia and rhabdomyolysis were linked to isotretinon therapy. Dopamine-Related Disruption of Functional Topography of Striatal Connections in Unmedicated Patients With Schizophrenia.

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Grass hay and Acacia fruits: a local feeding system for improved calf performance in semi-arid Ethiopia. Subsequently it proved to be a splice variant of the Nebulin gene and therefore was also termed LIM/nebulette. Our multicenter, prospective, observational study included 1553 patients with CKD (2009-2011). Our data show that children and adolescents with PWS are affected by psychosocial problems, and that restrictive feeding practices might be associated with more severe behavioral problems.

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The study also investigated the impact of search task familiarity on search behaviors and the effectiveness of the interface. Adherence to antipsychotic medication among homeless adults in Vancouver, Canada: a 15-year retrospective cohort study. Older adults with chronic pain appear to be less active than asymptomatic controls. Changes in the function of the adrenal glands of rabbits under the effect of cortisone, ACTH and sodium salicylate administration Natural killer cell activity in patients with gynecologic malignancies: correlation with histologic grading and stage of disease.

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Therapeutic responses to natural environments: using gardens to improve health care. This integration makes it possible to print 2D and 3D fluidic, electrofluidic, and electrical components on paper, and to fabricate devices using them.

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These results show that MIBK metabolites can potentiate the cholestatic form of hepatotoxicity. Metabolism-perfusion imaging to predict disease activity in cardiac sarcoidosis.

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Silymarin and PTX were associated with lower histopathologic liver damage, hepatocyte apoptosis, and regulation of extracellular matrix proteins. Especially, the last 5 years witnessed remarkable progress in apheresis science in Turkey, both in terms of increased numbers of therapeutic apheresis centers, therapeutic apheresis procedures performed per year, and also in terms of quality and standardization. Reliability analysis was performed using the Intraclass Correlation Coefficient.

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The changes in the composition of biomembrane PL were accompanied by an increase in the total cholesterol content in red cell biomembranes and by an increase in the total and free non-esterified fatty acids in blood plasma (P less than 0.05). In AS patients admitted to the hospital, C-spine fracture is a leading cause of in-hospital mortality.

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Lymphedema is divided into primary and secondary forms based on the underlying etiology. This case report describes the interdisciplinary treatment of a 39-year-old man with several missing teeth (including both maxillary lateral incisors), Class II malocclusion, deep overbite, and significant mandibular midline deviation. Numerous clinical studies have reported that ingestion of chocolate has reduced risk of metabolic syndrome. Platelet ultrastructural alterations representing spurious activation have been identified in pathological conditions.

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In vitro experiments showed that TWIST1 overexpression inhibited the transdifferentiation of VICs into osteoblasts by decreasing the expression of runt-related transcription factor 2 (RUNX2) and its downstream osteoblastic markers. Our work indicates that Csa and Csb, two genes involved in TCR, are preferentially required to protect against cisplatin ototoxicity, relative to global genome repair-specific elements of nucleotide excision repair, and suggests that TCR is a major force maintaining DNA integrity in the cochlea. Differential effects of D- and L-amphetamine on behavior and on catecholamine disposition in dopamine and norepinephrine containing neurons of rat brain. By this procedure which is a new combination of well know tests, Salmonella spp. The free rotated papilla autograft--a bilaminar procedure for the coverage of multiple shallow gingival recessions: a biometric evaluation.

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Making our memories last: the necessity of an early neocortical tagging process With a peak incidence in the fifth decade of life, its early recognition and intervention are key to successful treatment and better prognosis of patients. a redox proteomic approach was used to investigate total and specific protein carbonylation and protein-bound 4-hydroxy-2-nonenal (HNE) in the serum of AAA patients compared with age-matched controls. The study was retrospectively designed, albeit with prospective implications for analytic investigation.

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Vaginal vesicostomy for empyema of the defunctionalized bladder. Auxiliary acetabular cerclage-wiring is a safe and effective method for fracture reduction and retention especially in displaced acetabular fractures involving the quadrilateral plate. The membrane threshold shift in nociceptive fibers is an important prerequisite for pain perception in nerve root compression. Risk-scoring models for individualized prediction of overall survival in low-grade and high-grade endometrial cancer. In this issue of AJG, the subject of polyp detection rates (PDRs) and adenoma detection rates (ADRs) in the proximal and distal colon is discussed by one group of investigators to address the issue of monitoring performance and to achieve improvement.

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Morphological characteristics such as the brain, mouthparts and legs were identifiable in both living and preserved samples, with distinct differences noted between the two ages. Comparison of discrete models of charge transfer in thin membranes. Afadin is an actin-binding protein that interacts with the intracellular region of the transmembrane proteins, nectins. They were instructed to choose 1 in each pair as the preferred date, preferred friend, more charismatic boss or as the better national leader. In the past 3 decades, a number of new models have been proposed, yet researchers still find it difficult to select appropriate models for data and objectives.

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Titration of the thiols of CF1 and determination of their subunit distribution before and after activation by dithioerythritol show an increase of the free groups from 8 to 10 with the appearance of the 2 new thiols on the gamma subunit. The main results are as follows: No score is sufficiently reliable to predict the success of reconstruction. Child and adolescent (early onset) schizophrenia: a review in light of DSM-III-R. The objectives of this study were: 1) to measure the diagnostic accuracy of the osmole gap for screening for ethylene glycol and methanol exposure, and 2) to identify whether a recently proposed modification of the ethanol coefficient affects the diagnostic accuracy. The use of objectively measured BMI is preferable as it will provide more accurate estimates of weight misperception.

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Bariatric surgery is becoming more appealing as an option in addressing adolescent obesity. It was, however, equally effective at reducing the survival of Staph. Cholecystectomy remains the gold standard treatment of cholecystitis. Temporal response properties of lumbar-projecting vestibulospinal neurons to roll tilt in decerebrate cats. Training module for cheiloscopy and palatoscopy in forensic odontology.

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The aim of this study was to identify factors predicting successful aAVF maturation and to determine positive technical aspects of sPTA. We present strong experimental data supporting our view that the transcriptional defects observed in UV-irradiated CSB cells are largely the result of a permanent transcriptional repression of a certain set of genes in addition to some defect in DNA repair. Crystallinity and framework aluminum site accessibility were found to be critical to achieve high aromatic yields. ProKinO: an ontology for integrative analysis of protein kinases in cancer. To evaluate the long-term outcomes of a non-valved, Chinese-made Hunan aqueous drainage device (HAD) in patients with refractory glaucoma, compared to trabeculectomy.

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The authors compared retinal blood flow in rats after 5 weeks of streptozotocin (STZ)-induced diabetes with that in age-matched control animals. The length and width of reconstructed ears,which represented the swelling degree, were measured instantly and 5, 10 days postoperatively.

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Thus, miR-8 regulates Drosophila immune homeostasis by targeting multiple immune genes, thereby contributing to survival. The haemostatic system is heavily involved in the host response to infection. The rat hippocampal slice preparation was used to study the combined effects of hypoxia and lactic acidosis on neuronal function. Age, MELD score, and encephalopathy are independent risk factors.

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Ammonia entering the brain is quickly trapped by the ATP-consuming glutamine synthetase reaction leading to energy depletion in the reticular activating system. An erythema annulare-like lesion following the intramuscular injection of a suspension of estrogen and progestative mixture in purified olive oil is described by the authors. Interaction of suriclone with central type benzodiazepine receptors in living baboons.

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Acute restraint stress did not alter angiotensin II-induced contraction in carotid arteries from normoglycaemic rats. The high throughput system using iPSC-derived cardiomyocytes for the detection of beta1-AAB provides a realistic option to overcome the sample-size limitations of the bioassay-based diagnostics. In this study, we identified three novel and 22 known mutations in FBN1 in 34 of 40 EL families.

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Microporous aluminophosphate nanosheets and their nanomorphic zeolite analogues tailored by hierarchical structure-directing amines. Some further observations on paper chromatographic separation of amino acids from untreated urine samples.

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South Asians are more prone to develop metabolic syndrome (MetS). Cases with a stable diagnosis showed significantly more core ASD symptoms in adolescence/young adulthood.

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We report a case of juvenile gastric polyposis associated with antiphospholipid syndrome. It occurs most often in children who have an underlying predisposing disorder that can result from anatomic fistula or immunodeficiency.

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Hemodynamic and humoral effects of the novel calcium antagonist Ro 40-5967 in patients with hypertension. Recurrent and acquired hepatitis C virus infection in patients after liver transplantation

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Possible reasons for the different results obtained in the two research groups are discussed. These are assembled from thousands of protein subunits translocated across the cell membrane by an export machinery at the base of each flagellum. In total 281 patients (128 men and 153 women) were included in the study and all patients underwent elective general surgery. Postoperative nausea and vomiting (PONV) events were recorded for 24 h.

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A retrospective review of neuroleptic dosages over a five-year period in 19 chronic schizophrenic patients revealed that the majority (85 percent) had either consistent yearly increases or decreases in dosage, although clinical status remained unchanged. The intervention analyzed was stapler-assisted pharyngeal closure, whereas the control group was manual suture pharyngeal closure. There were no sensory or bulbar symptoms, scoliosis, long tract signs or lower limb involvement.

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Therefore, a tailored eradication regimen based on antibiotic susceptibility and maintenance of acid inhibition should have a high success rate. Developmental abnormalities of the thymus in hea/hea mutant mice. Ninety-six patients with temporomandibular joint disorder including 54 patients with myofacial pain and 42 patients with external pterygoid muscle spasm, were invloved and then divided into electroacupuncture group and massage combined with electroacupuncture group equally and randomly, with 48 cases in each group. PFS was significantly longer in responders than nonresponders on both MRI at 4 and 8 weeks and MET-PET at 8 weeks, whereas MET-PET at 4 weeks provided no information regarding outcomes. TSH assay of the 3rd generation decisively improves the diagnosis of hyperthyroidism and probably also borderline hyperthyroidism.

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Rebuttal to EP testing predicts cardiac events in patients with Brugada syndrome. Any individual in whom no morphine or codeine was detected in a postmortem sample was excluded from further study.

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Quality of life in patients with diabetes mellitus before and after their participation in an educational program It also extrapolates from the Vietnamese manicure experience propositions concerning the development, expansion, maintenance, and transnationalization of immigrant-formed labor market niches. Improved individualization of therapy may be accomplished by the use of newer ACE inhibitors with very favorable side effects profiles and tissue specificity.

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Humic acid causes diseases including lung emphysema and fibrosis. The microTS of the latter was higher than that of the other two HEMA-free adhesives for each air-drying time. The aim of this study was to develop a strategy to determine a sound methodology for decision-making in lumbar spinal canal stenosis (LSCS). Tendon is one of the least understood tissues of the musculoskeletal system in terms of development and morphogenesis.

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To evaluate whether MR thermometry is sufficiently fast, accurate, and spatially resolved for monitoring the thermal safety of nonablative pulsed high intensity ultrasound (pHIFU) treatments. Subjective tinnitus is usually associated with a hearing loss, and therefore, the clinical evaluation is focused on an otologic and audiologic evaluation with adjunct imaging/tests as necessary. Collagen fiber density and alignment relative to the epithelial surface significantly increased within the first twelve hours and were a major influence in the shaping of the mammary epithelium.

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One year later, reoperation was successfully performed for the replacement of the stenotic VPR with a transannular patch. Culture of melanoma cells on type I collagen increased the activation state of MT1-MMP. Nonspecific symptoms of pain syndromes of cervicobrachial localization and their dynamics under the influence of non - pharmacological treatment

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Considerations on alterations in brain activity in patients with fibromyalgia This paper reports on an experiment conducted to study the effects of reflective practice on diagnostic accuracy. A mixed anti-inflammatory and pro-inflammatory response associated with a high dose of corticosteroids. During this video, we show a redo paraesophageal hernia repair in which we were unable to achieve adequate esophageal lengthening despite extensive mediastinal dissection.

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Spatio-temporal pattern of frequency representation in the auditory cortex of guinea pigs. A literature search was performed in Medline, Embase and the Cochrane library to identify papers reporting on radiological criteria to describe LSS and systematic reviews investigating the effects of different treatment modalities. Deep sequencing of CPV-resistant laboratory isolates identified a frameshift mutation in UL27, presumably to compensate for a loss of UL97 enzymatic activity. Male HFD obese and HFD-PF non-obese rats had similarly reduced expression of Bdnf compared with LFD males, indicating that dampened Bdnf expression was associated with feeding a diet high in fat instead of increased adiposity. High efficiency Tm:YAG slab laser with hundred-watts-level output power.

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Our model predicts that the circadian rhythms of cortisol, our proinflammatory mediator, and its receptor exhibit seasonal differences in amplitude and phase, oscillating at higher amplitudes in the winter season with peak times occurring later in the day. To formally test whether insulin sensitivity mediates the relationship between fitness and brain integrity.

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Vaccination status was ascertained by parent report and review of patient-held records where available, and by serological testing for immunity to hepatitis B, tetanus, diphtheria, rubella and measles. A prospective study of 12 patients with sagittal plane imbalance after multiple surgeries for scoliosis is reported. Furthermore, the results from the western blot analysis demonstrated that augmenting ADR treatment with germacrone resulted in a reduction of anti-apoptotic protein expression levels (bcl-2) and enhancement of pro-apoptotic protein expression levels (p53 and bax) in MCF-7/ADR cells compared with the levels achieved by treatment with ADR alone. The patient underwent surgery with gross total removal of the tumour and relief of his initial chief complaint of visual blurring.

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Metal-free protodeboronation of electron-rich arene boronic acids and its application to ortho-functionalization of electron-rich arenes using a boronic acid as a blocking group. The aim of the current study was to examine the influence of adiposity on the relationship between SBP and underlying haemodynamic mebendazole tablets buyers mechanisms in young adults.

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