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We sought to evaluate the clinical activity of enzalutamide versus docetaxel in men with mCRPC who progressed on abiraterone. Electrowetting-on-dielectric (EWOD) is a new method for moving liquids in biofluidic chips through electrical modification of the surface hydrophobicity. Results indicate that prediction of blood transfusions can be further improved by predictive modelling including individual pre-surgical parameters. High frequency physiologic data are routinely generated for intensive care patients. The abundance of treatment options, however, comes with specific challenges for the practical management of palliative medical therapy in advanced CRC, in particular with regard to the utilization of targeted agents.

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Some notes on the epidemiology of nonspecific ulcerative colitis. High-accuracy reference standards for two-photon absorption in the 680-1050 nm wavelength range.

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Autoregulation and multifunctionality among trans-acting factors that regulate alternative pre-mRNA processing. Our results help paving the way for establishing photoelectron holography for probing spatial and dynamic properties of atoms and molecules. Practical considerations such as the age, gender, and systemic health of patients and the nature of the disease process also need to be taken into account in order to personalize the treatments and progress towards developing a clinically applicable gene therapy for healing bone defects. Three-dimensional fibrous scaffolds provide an environment that enhances transplanted stem cell survival in vivo and facilitates imaging their localization, viability, and growth in vivo. Development of resistance to polyene antibiotics in Candida albicans.

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Our findings not only reveal a novel function of MDSCs in connecting inflammation to cancer, but also provide a rationale for developing effective therapeutic strategies to subvert inflammation- and tumor-induced immunosuppression. We examined use of aspirin, angiotensin-converting-enzyme (ACE) inhibitors, beta blockers, and statins during the following seven in-hospital periods: admission, presurgery, the day before surgery, the day of surgery, the day after surgery, postsurgery, and discharge.

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Aphasia and deafness in children--some aspects of differential diagnosis. HIV infection as a consequence of blood transfusions and blood by-products has occurred in many developed countries from the outset of the HIV/AIDS epidemic.

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CKD and Cardiovascular Events: Unraveling the Disparities Among Minorities. An increase in seizure frequency, occurrence of side-effects, and seizure severity were all significantly associated with lower utility values. The rate and pattern of nucleotide substitution in Drosophila mitochondrial DNA. In the other 19 (II group) the treated tooth was isolated only by cotton rolls. Application of pelvic area as a new morphometric variable in man.

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However, outbreaks of coccidiosis still occur and subclinical infections, which significantly impact on productivity and food security, are common due to widespread drug resistance, high parasite prevalence, and environmental persistence. Frequent oral PPI may be able to replace the currently recommended intravenous bolus plus infusion PPI therapy in patients with bleeding ulcers, although the possibility that intravenous PPIs are superior cannot be definitively excluded given our relatively wide confidence intervals. The glycocalyx constitutes the first line of the blood tissue interface and is thus involved in many physiological processes, deregulation of which may lead to microvascular dysfunction. Whereas over-expressing Imp-L2 strongly reduces size, loss of Imp-L2 function results in an increased body size.

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Volumes of interest (VOIs) were delineated on pretreatment contrast-enhanced CT or MR images according to Couinaud liver segmentation. Cyanobacteria are little explored in this context because most of the drugs in human therapy are derived from microorganisms, mainly bacterial, fungal and actinomycetes. Aberrant DNA Methylation: Implications in Racial Health Disparity.

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Striking similarities were found in molecular weight, isoelectric point and degree of heterogeneity for human and mink SAA, while immunologic cross-reactivity between the two species was not found. An 87-year-old man presented with a 1-week history of transient facial numbness, followed by the onset of left diplopia 1 month later. Our genetic operators guarantee the feasibility of solutions over the generations of population, which significantly improves the computational efficiency even when it is combined with our flexible adaptive searching strategy. Dominance relationships in 75 of the possible 231 pairs of alleles have been determined in both pistil and pollen.

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In addition, the unit for a dominant (high visibility) group inhibits the unit for a subordinate (low visibility) group, thereby decreasing the visibility of the subordinate group. Analysis of the results shows a tooth wear distribution that is significantly different between upper and lower horizontal and oblique directions in females and males, and between upper and lower horizontal and oblique heavy wear in females and males. Systematic Review of Liposomal Bupivacaine (Exparel) for Postoperative Analgesia. Molecular screening techniques are available to identify hereditary Lynch syndrome in people with newly diagnosed colorectal cancer (CRC).

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Here, we provide protocols that have proven successful in such endeavors. This system was now studied at both the mRNA/cDNA and protein levels. We also performed 3 months echocardiographic and clinical follow-up. Demographical data, clinical symptoms and the ROMA index were separately analyzed and contrasted in benign and malignant in both menopause and pre-menopause patients.

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Retinal nerve fiber layer thickness and inner retinal layer thickness of optic nerve hypoplasia were significantly thinner than the opposite eye, but there was no significant difference in the thickness of the outer retinal layer between both eyes. Serotyping of nontuberculous mycobacteria, especially those of the Mycobacterium avium complex, provides important epidemiological information, particularly in tracing origins of infections. All 19 measurement items were assessed by SPSS 17.0 software package.

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To evaluate the sensitivity, specificity, and accuracy of time-of-flight MR angiography (MRA) compared with CT angiography (CTA) for detection of branch vessels arising from the intracranial aneurysm sac, using a 3-tesla MR scanner and an area detector CT scanner. Graft rates are not high but are mostly noted in electrical burns. Recent studies indicate an increase in tumor progression and recurrence in head and neck squamous cell carcinomas (HNSCC) of cancer patients taking recombinant human erythropoietin (rhEpo) for anemia.

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Fitness was favorably associated with aortic IMT and elasticity in adolescents. In vivo experimentation confirmed that hydrogels containing higher electrostatic charge and low crosslink density are more effective at fostering the formation of a robust hemostatic plug to control blood loss. ON THE ACTION OF A NEOMYCIN-THIOPHENICOL ASSOCIATION ON EXPERIMENTAL ACUTE INTESTINAL OCCLUSION Fetal trophoblast is generally resistant to lysis by cytotoxic cells. Use of anaesthesia care for emergency EGD was associated with increased mortality, most likely because of confounding by indication.

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Significance and evaluation of theophyllinemia in clinical medicine Improving resolution in multidimensional NMR using random quadrature detection with compressed sensing reconstruction. A facile approach using click chemistry is demonstrated for immobilization of metalloporphyrins onto the surface of silica-coated iron oxide particles.

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Adults with recurrent/refractory RMS were treated with ifosfamide (1,800 g/m(2)/day), etoposide (100 mg/m(2)/day) and mesna (1,080 mg/m(2)/day) for 5 days. On 3 April 2012, we searched the Cochrane Neuromuscular Disease Group Specialized Register (3 April 2012), CENTRAL (2012, Issue 3), MEDLINE (January 1966 to March 2012), EMBASE (January 1980 to March 2012), CINAHL Plus (January 1937 to March 2012), AMED (January 1985 to April 2012), LILACS (January 1982 to March 2012), PsycINFO (January 1806 to March 2012), PEDRO (29 January 2013) and clinical trials registers (29 January 2013).

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Expression of high levels of nitrobenzylthioinosine-sensitive nucleoside transport in cultured human choriocarcinoma (BeWo) cells. Cytogenetic abnormalities in a squamous cell carcinoma of the penis. These procedures were performed for each patient once per week for five weeks. The gastroprotective effects of B-Hb are accompanied by inhibition of neutrophils activity, reduction of oxidative stress and maintenance of mucosal integrity.

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Additionally, varied ZAP-70 inhibitors published in different patents and papers have also been reviewed. The aim of this paper is to automatically extract hidden topics from Web-based physician reviews using text-mining techniques to examine what Chinese patients have said about their doctors and whether these topics differ across various specialties. Pregnancy-related hospitalizations with stroke were identified according to the International Classification of Diseases, Ninth Revision. Herein, a new class of mobile genetic elements is proposed in the form of circulating nucleic acids (CNAs) derived from the billions of cells that die in the body every day due to normal physiology and that act intra-corporeally.

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Yet, many of the biological processes of members of the order Herpesvirales are similar. Lectin histochemistry revealed pregnancy related changes in three portions of mouse endometrium: endometrial glands, luminal epithelium and its basement membrane. Small cell lung cancers (SCLC) are tumors of neuroendocrine origin. Mindfulness-Based Cognitive Approach for Seniors (MBCAS): Program Development and Implementation. The ZnO nanowire arrays used as photocatalysts present good photocatalytic performance to the degradation of methyl orange (MO) due to the large surface area.

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Logistic regression analysis was used to assess the relationship between the EWS and the occurrence of the composite endpoint consisting of death, reanimation, unexpected intensive care unit admission, emergency surgery and severe complications. Infants with single ventricle require staged cardiac surgery, with stage I typically performed shortly after birth, stage II at 4 to 6 months of age, and stage III at 3 to 5 years of age. The results showed that the cocaine-induced CPP persisted over two weeks in C57BL/6J mice, while it diminished within one week among BALB/cJ mice. High frequency of multiple paternity in broods of a socially monogamous cichlid fish with biparental nest defence.

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MAGeCK-VISPR is freely available at http://bitbucket.org/liulab/mageck-vispr . This new method is simpler than the standard Ficoll-Hypaque method for PBLs separation and Proteinase K digestion for DNA extraction. Influences of changes in calcium concentration and verapamil on the cardiac depressant effect of ethanol in cat papillary muscle. Perceived social pressures and the internalization of the mesomorphic ideal: The role of drive for muscularity and autonomy in physically active men. Retrospective analysis of clinical case notes and coronary angiography reports.

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Self-assembled polymeric vectors mixtures: characterization of the polymorphism and existence of synergistic effects in photodynamic therapy. Gastrointestinal dysfunction remains a major cause of morbidity and mortality. Two independent authors selected studies and abstracted the data. Chloroplast markers have greatly improved our understanding of this clade but many relationships remain unclear primarily due to low levels of molecular evolution and recent and rapid divergence.

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Towards highly active and robust alkyne metathesis catalysts: recent developments in catalyst design. Analysis of heart rate variability using an autoregressive model and treadmill exercise ECG test Factors affecting patient outcome following surgical correction of scoliosis were assessed. Expenses for the fabrication of the shields were covered by the main author (L.P.B.P.).

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Retinal detachment is the physical separation of the retina from the retinal pigment epithelium. Leptospirosis in pregnancy with pathological fetal cardiotocography changes. Fifteen patients were in the PKT group and 17 patients were in the non-PKT group. Diagnostic and therapeutic applications of antiplatelet monoclonal antibodies. Correction: Massive right hemothorax as the source of hemorrhagic shock after laparoscopic cholecystectomy - case report of a rare intraoperative complication.

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Our comprehensive meta-analysis confirms a substantial genetic contribution to sporadic IA, implicating multiple pathophysiologic pathways, mainly relating to vascular endothelial maintenance. The challenges in securing informed parental consent, especially on religious grounds, and meeting the financial burden of this emergency procedure to facilitate timely ET are examined. Before and after the surgery, patients completed a Bristol Female Lower Urinary Tract Symptom-Short Form questionnaire. The incidences of other predisposing factors were: previous abdominal surgery (1/3), heavy lifting (2/3) and multiparity (2/3). The introduction of the degree of dominance provides useful insights into the mode of inheritance in GAS.

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Endometrial Adenocarcinoma Presenting as Hematometra with Underlying Thickened Endometrial Lining in a Postmenopausal Woman - A Case Report. Gangrene of the penis, scrotum, and perineum, occurred after radiotherapy of rectal cancer. Our findings demonstrate that longer DUP in FES patients is associated with worse cognitive scores, and that this association is more pronounced in a subgroup of patients who have lower premorbid intelligence. Characteristics of pregnant women in Mozambique--parity, child survival and socioeconomic status.

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Five cases of human immunodeficiency virus Type 1 (HIV-1) RNA-positive blood donations are described that escaped detection by three different CE-marked nucleic acid amplification technique (NAT) screening assays. Downregulation of the long noncoding RNA TUG1 inhibits the proliferation, migration, invasion and promotes apoptosis of renal cell carcinoma. Extracellular adenosine-mediated modulation of regulatory T cells. Our results indicate that affective temperament measure along with Gotland Scale for Male Depression could be useful tools in screening and identifying those affective disorder patients who are at higher risk of suicidal behavior. If a patient has a chronic wound at the location of the endoprosthesis or stump prosthesis after amputation, the possibility of benign air entrapment should be routinely considered.

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The relationships between respiratory and blood gases in the control of total body perfusion. Nephrectomy and natural orifice translumenal endoscopy (NOTES): transvaginal, transgastric, transrectal, and transvesical approaches. Further primary clinical articles on risk factors for revision of TKA are necessary to ensure maximal function and lifespan following TKAs. Practical application of measles and rubella vaccinations 12 years later

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Several lines of experimental evidence suggest that loop E might be involved in binding or stabilizing functional manganese in the catalytic site of water oxidation or in interacting with the extrinsic PS II-O protein (the 33-kDa manganese-stabilizing protein). Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. The dynamics of choline acetyltransferase and acetylcholinesterase changes in dog spinal cord during ischemia. There was evidence for airway epithelial cell hypertrophy and hyperplasia. Additive effects of prostaglandin E2 and pulsed electromagnetic fields on fracture healing.

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