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Piramax (Topiramate)
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Topiramate

Piramax is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Piramax antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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For these reasons, in recent years, the scientific community has been interested in proposing methods and protocols to investigate HRR and understand its underlying mechanisms. Numerous species of gall midges (Diptera: Cecidomyiidae) have been recorded from saltbush (Chenopodiaceae: Atriplex) around the world but only 11 of them belong to the large cecidomyiid genus Asphondylia.

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Importantly, mutations in Rv0900 and/or Rv0901 strongly altered OmpATb expression, demonstrating that Rv0900 and Rv0901 play a regulatory role, which appears to occur at a post-transcriptional level. Increasing doses of simvastatin versus combined ezetimibe/simvastatin: effect on circulating endothelial progenitor cells. Altered neutrophil function induced by serum from patients with systemic lupus erythematosus.

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MALDI-TOF-MS reveals differential N-linked plasma- and IgG-glycosylation profiles between mothers and their newborns. Parallel spectroscopic evidence indicates that apo-DNR binds heme in vitro and that the heme-bound form reacts with carbon monoxide and NO, thus supporting the hypothesis that NO sensing involves gas binding to the ferrous heme.

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Here we show that enteric neurons play a major role in regulating feeding through specialized mechanosensory ion channels in Drosophila. In practical terms, these suggest that certain materials, notably silicone and C-flex, are more suitable for ureteral stenting than others.

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Heparin cofactor II (HCII) is a thrombin inhibitor in human plasma which displays similarities with antithrombin III (ATIII). Alternatively, variable responses among species could originate from differences in permeability of dormant life-stages to lipophilic chemicals like rotenone. Role of the parietal cell in gastric damage induced by aspirin and related compounds.

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Angiographically, bleb-like aneurysms were more frequent in the ICA group and fusiform aneurysms were more frequent in the VA group. Metalloproteinases (MMPs), including MMP-2, play critical roles in tissue remodeling and are involved in a large array of pathologies, including cancer, arthritis and atherosclerosis.

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This meta-analysis indicates presurgery emotional distress has significant associations with postoperative outcomes but specific methodological factors and sample characteristics contribute to effect size variability in the literature. Then the application development of nanomaterials with dual-modality in cancer field is discussed. The extracts of the stomach contained large amounts of insulin immunoreactivity while insulin was not detectable in extracts of the small bowel.

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We report transhepatic permanent ventricular lead implantation for a young boy with heterotaxy complicated by complete heart block. Emergency bronchoscopy for foreign-body aspiration in a child with type I mucopolysaccharidosis: a challenging airway management experience. Costs of day hospital and community residential chemical dependency treatment. On the electron-transfer-coupled proton release of cytochrome c. Baseline milk production was determined by measuring the volume of milk collected on the 1st postpartum day, before initiation of study medication (day 0).

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The clinical findings ascribed to trisomy 1q and partial monosomy 9p are summarized and compared to this case. The impact of components of fine particulate matter on cardiovascular mortality in susceptible subpopulations. Determination of triamcinolone acetonide in cream and suspension formulations by high-performance liquid chromatography. Hawaiian propolis contained nine prenylflavonoids that were also isolated from Okinawan propolis.

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Here we present the results of whole-genome metagenomic analysis of electrochemically active robust anodic microbial communities, and their anaerobic digester (AD) sludge inocula, from two pilot-scale MFC bioreactors fed with different distillery wastewaters operated under ambient conditions in distinct climatic zones. It is shown here that by simply altering the conditions (pH or ionic strength) of the environment prior to electrophoresis, a different migratory profile for S1 emerges, yielding a collection of bands, all of which migrate faster than the parent band. The effect of fitting procedure on hearing protector attenuation. A charitable home nursing service was set up as a result of this study and this is described. Effects of ibopamine on the increase in plasma norepinephrine levels during exercise in congestive heart failure.

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The quinazoline derivative RG3039 has advanced to early phase clinical trials. Optimization of tribological and mechanical properties of nanocomposites of polyurethane/poly(vinyl acetate)/CaCO3. However, early corticosteroid therapy must be prescribed when the lesion is located in a dangerous area, such as the eyelids or the lips. RS3-MLVA16 also underlines genetic variability within the same MLST-type and clonal complex, and gives a first overview of population structure.

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Laminin A, B1, B2, S and M subunits in the postnatal rat liver development and after partial hepatectomy. Awareness of disease in dementia: factor structure of the assessment scale of psychosocial impact of the diagnosis of dementia. Non-invasive measurement of adrenocortical and gonadal activity in male and female guinea pigs (Cavia aperea f. Variations in activity and sexual dimorphism of central nervous neurons in the rat in the course of postnatal development

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Here we reveal the orientational properties of semiflexible polymers in electrospun nanofibers, which allow the polarization properties of active fibers to be finely controlled. The pilot course was held in June 2012, and focused on analyzing contemporary issues related to global health diplomacy through the framework of actors, drivers, and policies that affect public health research and capacity-building, beginning at the level of global health governance and cooperation and moving progressively to regional (supranational), national, and institutional perspective. Various radiosensitivity levels were shown among the loci studied.

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Inhibition of return shortens perceived duration of a brief visual event. In the context of RNA architectures as structural scaffolds, there are clear parallels between DNA origami and the recently emerging molecular mechanism of heterochromatin formation by Xist RNA. After completion of this article, the reader should be able to explain the scientific evidence concerning the effectiveness of various techniques used for continuing medical education, state the relative value of such techniques as traditional didactic lectures, conferences led by local opinion leaders, interactive workshops, and educational outreach visits, and identify the value and limitations of teaching critical appraisal skills. Data from 500 patients, gathered in 1991/92 on sociodemographic and treatment characteristics, emphasize the long-term aspect of the methadone maintenance treatment and the necessity of an intensive psychosocial treatment. Understanding the spectrum of sinus venosus interatrial communications.

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Downregulation of ECM receptor-related genes may be associated with impaired angiogenic activity in ECs derived from iPSCs from patients with MMD. The DNA content and ribosomal RNA gene copy number in heart of the inbred mouse strain C57BL/6 were determined at different ages. Detection and separation of some arginine amidases including tissue kallikrein from human seminal plasma. Treatment of dysfunction of the auditory canal by finger massage of its pharyngeal opening in patients with chronic perforative otitis Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus.

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Active-grating monochromator for the spectral selection of ultrashort pulses. Discovery of a potentially deleterious variant in TMEM87B in a patient with a hemizygous 2q13 microdeletion suggests a recessive condition characterized by congenital heart disease and restrictive cardiomyopathy. Intra-operative cardiac output was unchanged compared to awake conditions due to a balance between reduced systolic and improved diastolic function. Case report of idiopathic portal hypertension with Cruveilhier-Baumgarten syndrome and portal thrombosis

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To this end, we examined six genes as potential disease modifiers. In this paper an international group of four informatics scholars illustrate some of the benefits and challenges of using mixed methods in evaluation. Sensory Processing in Rhesus Monkeys: Developmental Continuity, Prenatal Treatment, and Genetic Influences. In an era where access to information is virtually unlimited, an understanding of the preferred method of eye care education among patients is required for greater effectiveness in lowering morbidity and mortality of diseases. Targeting IL-33 was a promising strategy for controlling autoantibody production in AIHA patients.

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Clinical and pathological features of type I and III membranoproliferative glomerulonephritis Our objective in this study is to synthesize existing experimental data by constructing a realistic neuromechanical control model of rabbit nictitating membrane (NM) movements. Depression is associated with prolonged and complicated recovery following colorectal surgery.

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Methicillin-Resistant Staphylococcus aureus Otic Capsule and Pontine Infection Masquerading as an Internal Auditory Canal Neoplasm. This study is a retrospective review of 30 patients with polycystic kidney disease analyzing the quantitative measurements of renomegaly reported in the literature and the correlation of radiographic findings with the clinical complications of uremia, hypertension, infection, and the need for dialysis. Intravenous immunoglobulin selectively decreases circulating autoantibodies in pemphigus. Animals were sacrificed after 4 weeks for histological, microcomputerized tomography and gene expression analysis of the callus. Brain magnetic resonance spectroscopy (MRS) has been reported to be a valuable noninvasive tool in the diagnosis of some rare diseases.

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Pain levels after third molar surgical removal: an evaluation of predictive variables. injection of 2.0 mg BSA failed to produce the disease in Brown Norway (BN) rats. Here we screened validated target genes and immunity- related proteins, followed by analyzation of the mir-155 family function by high-throughput methods like the gene ontology (GO) and Kyoto Eneyclopedin of Genes and Genemes (KEGG) pathway enrichment analysis. Pregnancy and parturition of mice latently infected with Pseudorabies virus.

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Regulation of acetylcholine receptor transcript expression during development in Xenopus laevis. Many types of cases can be treated with the SAF system although a novice user is advised to advance slowly along the learning curve from simpler to more complicated canals. The nuclear lamina (NL) is thought to aid in the spatial organization of interphase chromosomes by providing an anchoring platform for hundreds of large genomic regions named lamina associated domains (LADs). The complete genomes of subgenotype IA hepatitis A virus strains from four different islands in Indonesia form a phylogenetic cluster.

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Cytogenetic monitoring of hospital workers exposed to low-level ionizing radiation. Molding the integration of children care in basic health attention

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Long QT Syndrome Leading to Multiple Cardiac Arrests After Posaconazole Administration in an Immune-Compromised Patient with bacterol forte para que es la Sepsis: An Unusual Case Report. In spite of these shortcomings, the review findings corroborate the idea that poor socioeconomic conditions are associated with periodontal outcomes, as demonstrated primarily by income and schooling indicators.

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Drug-resistant tuberculosis (DR-TB) is a major problem both in India and worldwide. The administration of chlorpromazine, vagostigumine, and gastrin induced a increase in spironolactone weight gain after stopping breastfeeding both celiac arterial flow and pedicle GEA graft flow. Does Target Object Processing Affect Reaction Times in Simple Detection Spatial Cueing Tasks? First, he described his brief life history, pointing out the four big identity crises in his life as his fierce struggles against the suicidal wishes were likely to enlarge within himself. Here, we report that the fission yeast CENP-B homolog Abp1 plays an important role in preventing pervasive transcription.

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Which treatments do children with newly diagnosed non-organic urinary incontinence receive? Data spironolactone 25 mg for hirsutism in women were assessed by Multivariate Profile Analysis, Analysis of Variance (ANOVA) and Multiple Comparison Tests of means. This review provides an overview on the prospects and advantages of microalgal protein expression systems and gives an outlook on potential future applications. Twelve individuals with Down syndrome, whose data were originally reported in Roch and Jarrold (2008), were seen four years later, and were given the same tasks as in the previous study evaluating phonological awareness, non-word reading and irregular word reading. The results suggest key improvements would be improving quality of counselling and making PMTCT guidelines available to health services.