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Zeclar (Clarithromycin)

Zeclar is a semisynthetic macrolide antibiotic, structurally very similar to erythromycin. It inhibits protein synthesis by penetrating the cell wall and binding to the 50S ribosomal subunit. The absolute bioavailability of Zeclar after oral administration is 50-55%, which probably underestimates its systemic activity, as it undergoes extensive first pass metabolism to its active metabolite, 14-hydroxyZeclar. Limited data are available on the distribution of Zeclar in humans. It appears to be distributed into most body tissues and fluids. However, no data is available on CSF penetration of Zeclar. Elimination of Zeclar follows nonlinear kinetics. It is extensively metabolized in the liver and excreted as parent drug and metabolites in urine, and faeces.

Other names for this medication:
Clarithromycin, Biaxin, Abbotic, Aeroxina, Biclar, Binoclar, Bremon, Clabel, Clamycin, Clarimac, Clarimax, Clarimed, Clarimycin, Claripen, Claritt, Clariva, Clariwin, Clarix, Claromycin, Claron, Cleron, Emimycin, Euromicina, Finasept, Fromilid, Infex, Kailasa, Kalixocin, Klabax, Klabet, Klabion, Klarimac, Klarimax, Klarithran, Klax, Klaz, Klerimed, Kofron, Krobicin, Lekoklar, Macladin, Maclar, Macrobid, Macrol, Monozeclar, Naxy, Synclar, Taclar, Veclam, Vikrol, Xylar, Zeclar, Zeclaren,

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Humoral immune response in disease-free advanced melanoma patients after vaccination with melanoma-associated gangliosides. The coordination of the different steps of embolization and neurosurgical treatment necessitate a preliminary multidisciplinary discussion of each case. Medical space, mission and apartheid in twentieth century northern Namibia. Polycentric focus effect of time-reversal (TR) electromagnetic field is found in a rectangular resonant cavity.

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Our findings, however, do support previous documentation that the intraocular pressure rise following orbital trauma with orbital emphysema is usually not of sufficient severity or duration to result in visual compromise. Synthesis of some new carbonitriles and pyrazole coumarin derivatives with potent antitumor and antimicrobial activities. This study analyzes the problems and consequences associated with prolonged use of laparoscopic instruments (dissector and needle holder) and equipments. It has been suggested that soy protein can slow renal disease progression by decreasing plasma cholesterol and proteinuria in patients with nephropathies.

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Expression of CADM1 is frequently downregulated in various tumors derived from epithelial cells. Patients with trauma are at increased risk of DVT and subsequent PE because of coagulopathy in patients with multiple trauma, DVT prophylaxis is essential but the VTE prophylaxis strategy is controversial for the trauma patients.

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Osteoporotic fractures: an unusual presentation of haemochromatosis. The genotypes of specific HLA region were evaluated for distinguishing the segregation of haplotypes among the family members, and primary HLA matching was performed between the embryos. The aim of the present study was to assess whether epigenetic control of MUC4 expression can sensitize pancreatic cancer cells to gemcitabine treatment. INCREASE OF FREE CORTISOL IN PLASMAS OF PATIENTS WITH TOXEMIA OF PREGNANCY. The Agency, for the first time, has set aside funds specifically for breastfeeding promotion and is working to identify places in its programs where such promotion can take place.

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The targeted introduction of mutations utilizing sequence specific transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system (RNA-guided nucleases, RGNs) has revolutionized reverse genetic approaches in numerous model organisms. Bacteriochlorophyll and chlorophyll share a common biosynthetic pathway up to the precursor chlorophyllide. Risk of malignancy associated with a maternal family history of cancer. This lack of vibration rendering limits the simulation fidelity of a surgical drill such as that used in temporal bone dissection. Some results of metabolic investigations in cases of renal stone.

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A series of assessments were performed before the first transplantation, including laboratory tests, CDCC Infant Mental Development Scale, and Gross Motor Function Measure-88 (GMFM-88). We present the case of a radiation-induced meningioma growing around a ventricular catheter that was not noted at an early stage as a result of artifact from an overlying shunt. In terms of physiological oxidative stress, induced tissue attack is minimal. However, longstanding methods of ERCP-guided tissue acquisition (i.e., biliary brushings for cytology and intraductal forceps biopsy for histology) have demonstrated disappointing performance characteristics in distinguishing malignant from benign etiologies of IDBSs. In contrast to the findings of other authors no increased ATP content was observed.

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In the present study, arginine (Arg)-rich CPPs containing unnatural amino acids were designed to deliver plasmid DNA (pDNA). This article frames an approach to CTCRD based on the American College of Cardiology/American Heart Association stages of heart failure (HF).

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Platelet membrane glycoproteins (GP) II b HPA-3 gene polymorphism was detected by polymerase chain reaction (PCR) method. Synthetic approaches to pyridazino(2,3-a)-1,3,5-triazines, a novel heterocyclic system. In this study, we attempted to create a cysless mutant ABCG2 as a tool for further characterization of this molecule. Clinically relevant multidrug resistant Salmonella enterica in swine and meat handlers at the abattoir. We report two siblings from a consanguineous Pakistani family who presented with cerebellar ataxia and severe myoclonus from adolescence.

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In infected PBL-derived monocytes, HLA-DR increased, HLA-DQ decreased, and HLA-DP was unchanged. A strain of Pasteurella haemolytica isolated from goats in Uganda. Alkaline phosphatase of the developing down feather: substrates, activators, and inhibitors.

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Household food insecurity (HFI) has been shown to be associated with one or multiple micronutrient (MMN) deficiencies among women and children. luteo-caerulea and were analyzed by gas chromatography mass spectrometry (GC/MS). Through a system of chemotherapy, sanitation with the provision of latrines and health education the RF assisted the Commonwealth Caribbean countries during the period 1914-1925 in controlling the disease. Here we summarize our current knowledge on the expression and functions of H1 variants in mammalian development and stem cell differentiation.

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Intracavernosal injection of vasoactive drugs is a safe, effective, and commonly used treatment for impotence in diabetic men. Specific decrease of serum cholesterol level as an effect of external drainage of bile Hospital Trusts may allow nurses to jump waiting lists for fast treatment, Health Secretary William Waldegrave declared last week. We utilized gold nanoparticles (AuNPs) and laser desorption/ionization time-of-flight (LDI-TOF) mass spectrometry (MS) with a matrix-free format. A Salmonella typhimurium cobalamin-deficient mutant blocked in 1-amino-2-propanol synthesis.

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The proposed hypothesis regarding acetylation of Rb2/p130 in tumor VS normal cells was found to be true in our case study of 36 tumor samples. The incidence of human papillomavirus (HPV)-positive head and neck cancers (HNCs) is increasing sharply worldwide, while their HPV-negative counterparts are showing a decreased frequency. Complete sequence determination and analysis of the Guangxi Phasianus colchicus (Galliformes: Phasianidae) mitochondrial genome.

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Seventy healthy Japanese adult males were randomized 1:1 to receive either DMB-3111 or trastuzumab as a single intravenous infusion (6 mg/kg) over 90 min. Some electrical and fabrication properties of virgin and recycled A-150 tissue-equivalent plastic. Data from experimental studies and small clinical trials indicate that transport of l-arginine, the substrate for nitric oxide (NO), and subsequent NO production are reduced in obesity induced hypertension. With gelatin zymography assays, we found that ALDH1-high cells and ALDH-low cells expressed pro-matrix metalloproteinase-2 (pro-MMP-2) irrespective of their coatings. Graph theoretical analysis was then applied to identify parameters at critical topological junctions of the network, which may represent the most effective therapeutic targets.

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ID delivery devices are not currently available for infants and children, but recent studies have examined skin thickness in this population and reported that it did not differ in proportion to body size in infants, children, and adults. However, whether this represents microscopic misdiagnosis or increased recognition of P.

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Finally we demonstrate that YidC is required for the intracellular survival of Mtb in human macrophages. This study provides insight for future research about the impact of physical activity on multiple sclerosis. The phosphorylation of both of these proteins is increased when PP4 levels are suppressed, and is reduced when PP4 levels are increased, with striking consequences for the fate of the cell. Radioprotection by Podophyllum hexandrum in the liver of mice: A mechanistic approach. ImmunoRFA led to improved survival and suppression of distant untreated tumor growth.

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NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML. Backward bending of the upper vagina noted in nonprolapse conditions was usually absent in patients with uterine prolapse. Apropos of the humoral and hypothalamic regulation of ACTH secretion Laparascopic Neurolysis of Deep Endometriosis Infiltrating Left Femoral Nerve: Case Report.

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It is shown that coupling an incident surface plasmon polariton to intercavity modes of the particle can dramatically change transmitted fields and plasmon-induced forces. Pharmacokinetic parameters are quite variable and considerably more work is needed to better describe the kinetic disposition of isradipine.

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The melolabial flap is a versatile technique for reconstruction of defects of the central face. Rivaroxaban is a factor Xa inhibitor that was recently reviewed by the Food and Drug Administration as a potential therapy to reduce the risk of recurrent atherothrombotic events in patients with acute coronary syndromes. Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.

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Thirty-one patients with schizophrenia and 65 age- and gender-matched healthy controls underwent DTI, and fractional anisotropy (FA) and mean diffusivity (MD) were measured in cross-sections of fornix tractography. MicroRNAs (miRNAs) are non-coding short molecules that post-transcriptionally control gene expression. This study was conducted to determine the behavioral responses and self-concepts of young children with self-limited but transiently disfiguring capillary hemangiomas involving the head and neck. In both models, the highest stress values occurred in the abutment during vertical and oblique loading.

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One month later than the end of CRT, consolidation chemotherapy with four cycles of docetaxel 75 mg/m(2) and cisplatin 75 mg/m(2) were administered at each 21 days. Tamoxifen, a synthetic antiestrogen, increases disease-free and overall survival when used as adjuvant therapy for primary breast cancer.

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Histologic observations of cases following replaced flap surgery. Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice. Affected microenvironment by chemotherapy is an avenue to promote phenotype which tends to resist on to be ruined.

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Evaluating interventions to reduce a pathogen in animals often begins with challenge trials, in which animals are deliberately exposed to the pathogen under controlled conditions. Although further investigations of the pharmacokinetics of Pueraria thomsonii flower isoflavones are needed, the results of the present study indicate active metabolism of Pueraria thomsonii flower isoflavones in the human intestine. Ultimately, this review highlights the paucity of high-quality and compelling evidence regarding the fundamental impact, in humans, of sex differences on arterial function and the moderating impacts of exercise on arterial function, adaptation and health at different ages in either sex. Our study realized a detailed assessment of the book and especially of its illustrations belonging to Francesco Salviati.

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Colour-coded 3D reconstruction proved to be valuable to illustrate topographic information that could be detected only with difficulty on examining the original axial scan. Subjects in their thirties differed from older subjects in movement patterns used to rise from a bed. The immobilized enzyme preparations were stable for several months in storage, and the enzyme columns could be used for 600-800 analyses.

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However, previous studies have used attenuation correction rather than prone imaging to increase the rate of SO studies. Our device executes all steps of single-cell processing, including cell capture, cell lysis, reverse transcription, and quantitative PCR. Excitation dependent Raman studies of self-seeded grown InN nanoparticles with different carrier concentration. This paper summarizes such diagnostics and discusses unanswered questions concerning underlying biology and standardization issues.

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Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. Prevalence of adherence to the physical activity guidelines, according to the accelerometer data, was estimated based on a Betabinomial distribution. Effect of Smo SiRNA-mediated Hedgehog Signaling Pathway Inhibition on Palatal Fusion. The two groups were similar on most of the socio-demographic parameters, biochemical and many of the clinical parameters like age, waist circumference, glycated haemoglobin, lipid profile and insulin use.

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Due to US contrast agents (UCAs) and contrast-specific techniques, sonography offers the potential to show enhancement of liver lesions in a similar way as contrast-enhanced cross-sectional imaging techniques. Laparoscopic salpingectomy can be safely performed in the leopard using a single portal access system. These include development of RFA devices and techniques, standardisation of the treatment protocol, including imaging and selection of patients, and establishment of a feasible post-treatment follow-up strategy. Different compounds in garlic are thought to reduce the risk for cardiovascular diseases, have anti-tumor and anti-microbial effects, and show benefit on high blood glucose concentration. The rate of differentiation towards BVH-positive cells increased up to tenfold in the presence of bone morphogenetic protein 4 or retinoic acid.

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Control of bleeding is important in parenchymal transection during laparoscopic liver resection. As the technology continues to advance, several image-guided tumor ablations have emerged to effectively manage primary and secondary malignancies in the liver.

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This review presents a broad survey of patents issued in the area of pharmaceutical cocrystals. To compare the effects of various STN-DBS parameters on freezing of gait and to determine whether such effects are more related to stimulation energy (usual voltages vs high voltages at 130 Hz) or frequency (130 Hz vs approximately half this frequency: 60 Hz). Expression of CD45, the major receptor tyrosine phosphatase present on T cells, is required for efficient coupling between the TCR and its signaling machinery. To study the prevalence of VRE and the mechanisms of resistance implicated among wild birds, 238 fecal samples were collected in 2010 from house crows (Corvus splendens) foraging on hospital waste in Bangladesh.

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Agriculture and the food industry have made remarkable advances in the past decades. It is found that the SV-graphene undergoes a phase transition from an initial ferromagnetic state to a ferrimagnetic state under a biaxial tensile strain.

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Experiments undertaken confirm that interval type-2 fuzzy realization outperforms its classical type-1 counterpart and back-propagation neural approaches in all experimental cases, considering link positional error as a metric. Human participants were asked to reach in complete darkness to an unseen finger (proprioceptive target) of their left target hand indicated by a touch. In a retrospective case series, 39 eyes of 38 patients with vasoproliferative retinal tumors received ruthenium-106 brachytherapy between 2001 and 2013.

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Fructose 2,6-bisphosphate was not a substrate for aldolase or fructose 1,6-bisphosphatase. Specifically, when cellulose nanofibers were added to hydrogels, morphologic analyses showed significant decreases in pore size and formation of three-dimensional well-oriented porous microstructure. T-maze footshock avoidance acquisition detected impairment from 9 to 12 months of age. This paper presents the methods that enables the integration of the main memory and file system management for NV memory.

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Effect of Exposure to Tobacco Smoke on Response to Anti-Tumor Necrosis Factor-Alpha Treatment in Patients with Rheumatoid Arthritis. One reason that they are avoided is the difficulty in interpreting the complex processed spectra and the regression vectors that arise from common calibration procedures like principal components regression or partial least squares regression. A total of 31 papers on evaluation of priority setting were identified. Selection for mating propensity in irradiated populations of the cotton boll weevil. Hyperbilirubinaemia was significantly correlated with the infants who appeared disinterested in feeds when assessed by clinical observations of apparent hunger and alertness at the onset of the test feed.

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Shallow nearshore habitats are highly valued for supporting marine ecosystems, but are subject to intense human-induced pressures. Results from follow-up testing one year after the intervention ended corroborated the results immediately following intervention. Efficacy and (pharmaco)kinetics of one single dose of rasburicase in patients with chronic kidney disease.

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Patient comorbidities play a larger role than the procedure selected in predicting short-term complications. After each scan, subjects rated their level of exhaustion and performed an N-back task to evaluate eventual decrease in cognitive performance.

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Comparison of four different methods for detection of biofilm formation by uropathogens. Administrative data are not sensitive for the detection of peripheral artery disease in the community.

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Comparison of outcome of asymptomatic to symptomatic patients older than 20 years of age with valvular aortic stenosis. To determine whether OFF signals in visual stimulation are required for OFF RGC dendritic development, the light-evoked responses and dendritic stratification patterns of RGCs in Spastic mutant mice, in which the OFF signal transmission in the rod pathway is largely blocked due to a reduction of glycine receptor (GlyR) expression, were quantitatively studied at different ages and rearing conditions. The Willow Microbiome Is Influenced by Soil Petroleum-Hydrocarbon Concentration with Plant Compartment-Specific Effects. The high incidence of coexisting fenestration and aneurysm suggests that congenital factors may play a role in the pathogenesis of cerebral aneurysm. Few studies have examined the impact of past and recent abuse of women on breastfeeding behaviour.

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Clinical factors take priority in determining late chemotherapy decisions when clear treatment choices exist. In contrast, mutation of Cys-252, which is the target for repression of DNA-binding activity under oxidative conditions, results in a strong decrease of Jun-specific activation of transcription. Studies confirm effectiveness of harm reduction for people who inject drugs. One SNP in BACE2 was associated with allergic asthma in the SLSJ study and replicated in the EGEA study before statistical correction for multiple testing. Acute and chronic hepatitis E have been associated with high mortality and development of cirrhosis, particularly in solid-organ recipients and patients infected by human immunodeficiency virus.

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This finding suggests that angiotensin-converting enzyme inhibition may provide a novel strategy to prevent cardiovascular events in these patients. 10 men and 10 women in the age range 35-45 years, and 5 men and 6 women norfloxacin 400 mg dosierung in the age range 50-55 years were tested. The observed axonal alignment with this technique was much better than that obtained by microsuture alone. RESEARCH ON THE EFFECT OF LIGHT AND DARKNESS ON THE GENITAL FUNCTION OF THE MOUSE

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Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives. The simulation results have shown that the permeability coefficient (log Ppampa) of drugs is linearly increased with increasing their distribution coefficient (log KD,M) to the lipid membrane, i.e., the hydrophobicity of the drug molecules. The following three regimens of anesthesia in mice were compared: (1) Ketamine 100 mg--xylazine 5 mg/kg b.wt. The role of protein moiety of tissue thromboplastin during hantavirus treatment ribavirin dosage its specific enzymatic modification by papain was studied.

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The purity of the compounds, the content and isomerisation in stock solutions were checked by HPLC methods prior to their dilution and application to the experimental animals. It is reported klindacin gel electrophoresis frequently that individuals with palatal clefts have a high occurrence of laryngeal/voice symptoms. Antigenemia, RNAemia, and innate immunity in children with acute rotavirus diarrhea. Hybrid Atomistic and Coarse-Grained Molecular Dynamics Simulations of Polyethylene Glycol (PEG) in Explicit Water.

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Spontaneous coronary dissection is a rare but potentially life-threatening condition. Pollinators discriminate among flowers based on these differences, and individuals whose pistillate-phase flowers are most different in color from their staminate-phase flowers make fewer seeds. The increment in standardized uptake value determined using dual-phase 18F-FDG PET is a promising prognostic factor in non-small-cell lung cancer. Further, we initiated the process of validating targets using in vendee lucon vs dunkerque france vitro binding and enzyme activity inhibition assays and provide initial findings of potential epigenetic effects in a clinical context.

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Enhanced depth imaging optical coherence tomography (EDI-OCT) and AF were recorded from all patients at 18 months follow-up. pylori brux dental crown infection and IBD that supports a possible protective benefit of H. To present the management strategy and outcomes for our series of superior semicircular canal dehiscence syndrome (SSCDS) patients.

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To understand the molecular mechanisms by which zeldox pfizer FGF2 antagonizes BMP7 activity, we also investigated the signaling pathways utilized by FGF2 in bovine disc tissue. In vitro and in vivo models are important tools to investigate the pathogenesis of metastatic uveal melanomas and develop treatments for the metastases. Using mutant alleles of the HIS4 gene that result in poorly repaired mismatches in heteroduplex DNA, we find that heteroduplexes often span a distance of 1.8 kb.

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Solid dispersions were introduced as a formulation strategy in the early 1960s to tackle this issue and are still an area of oral ribavirin dose for rsv intensive research activity. The primary sites were the retroperitoneum in three cases, the lower extremity in two cases and the jejunal mesenterium in one case. Recent studies show the existence of autophagy in cerebral ischemia, but no consensus has yet been reached regarding the functions of autophagy in this condition.

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Histopathological and immunohistochemical stains were employed using specific antibody for kefnir capsules sizes O. Patients with severe brittle BA had atrophic alterations, inflammatory mucosal infiltration, marked bronchial remodeling in spite of therapy with high doses of inhalatory corticosteroids. Aim of the study is that of retrospectively verify, through a multivariate analysis, the factors able to condition mortality in long-term care, paying particular attention to the nutritional status.